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Diss Factsheets
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EC number: 200-609-3 | CAS number: 65-45-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1946 or before
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study published in a peer-reviewed journal, according to scientific standards. Experimental details documented, but no data on acclimatization and housing. Results: Mortalities tabulated after 1 and 7 days, but no statistical determination of LD50. Performed 1946, before GLP and OECD guidelines were introduced. Sufficient numbers of animals investigated, but sex not stated.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Pharmacological and toxicological studies on salicylamide
- Author:
- Ichniowski CT & Hueper WC
- Year:
- 1 946
- Bibliographic source:
- J. Am. Pharm. Assoc. Sci. Ed. 35: 225-230
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Acute toxicity study with intraperitoneal application, otherwise similar to acute oral toxicity.
- GLP compliance:
- no
- Remarks:
- GLP not available at study time
- Limit test:
- no
Test material
- Reference substance name:
- Salicylamide
- EC Number:
- 200-609-3
- EC Name:
- Salicylamide
- Cas Number:
- 65-45-2
- Molecular formula:
- C7H7NO2
- IUPAC Name:
- salicylamide
- Details on test material:
- - Substance type: Pure test substance
- Physical state: Solid; yellowish white crystalline powder
- Melting Point: 138°
- Taste: Practically tasteless
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: 0.5% gum tragacanth in water
- Doses:
- 250, 500, 1000, and 1500 mg/kg body weight
- No. of animals per sex per dose:
- 10 (sex not specified)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations: 15, 30, 60, 90 min, 2, 3, 5, 24 h, daily until day 7; no weighing reported
- Necropsy of animals dying on test: yes
- Necropsy of survivors: not reported
- Other examinations performed: clinical signs - Statistics:
- none
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 500 - < 1 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No statistical evaluation; mortalities 2/10 at 500 mg/kg bw; 9/10 at 1000 mg/kg bw
- Mortality:
- Mortalities 1/10 at 250 mg/kg bw; 2/10 at 500 mg/kg bw; 9/10 at 1000 mg/kg bw; 10/10 at 1500 mg/kg bw
All mortalities within 2 h after application, except for one animal in the lowest dose group, which was reported to be in good condition, and whose time and circumstances of death are not stated - Clinical signs:
- Heavy depression (dose-dependent), hind leg paralysis
Recovery of survivors within 24 hours - Body weight:
- no data
- Gross pathology:
- Congestion and hemorrhages of the lungs
Hyperemia of the meninges
All other organs grossly normal
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.