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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
6 July 2010
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The substance is soluble in the dispersion medium. Conducting the experiment in a saturated solution limited dissolution of the bulk material, however, the reported particle size distribution is expected to be associated with increased uncertainty.
Qualifier:
according to guideline
Guideline:
other: CIPAC Method 187, Particle size analysis by laser diffration
GLP compliance:
no
Type of method:
Laser scattering/diffraction
Type of distribution:
counted distribution
Percentile:
D50
Mean:
796 µm
Remarks on result:
other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.
Percentile:
D10
Mean:
209 µm
St. dev.:
26
Percentile:
D50
Mean:
796 µm
St. dev.:
18
Percentile:
D90
Mean:
1 480 µm
St. dev.:
11

Average of three determinations. Standard deviation is of the three determinations.

Conclusions:
While conducting the experiment in a saturated solution may have limited dissolution of the bulk material, the reported distribution of small particles present in the sample is expected to have increased uncertainty. Both crystallite growth and dissolution are potential outcomes. However, considering the large size of the particles (D50 ca. 1mm, and in good agreement with visual observation) the results are considered to be adequate for the purposes of risk assessment.

Description of key information

D50 ca. 1mm, CIPAC Method 187, laser diffraction, Das 2010

Additional information

While conducting the experiment in a saturated solution may have limited dissolution of the bulk material, the reported distribution of small particles present in the sample is expected to be unreliable. Both crystallite growth and dissolution are potential outcomes. However, considering the large size of the particles (D50 ca. 1 mm, and in good agreement with visual observation) the results are considered to be adequate for the purposes of risk assessment.