Registration Dossier
Registration Dossier
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EC number: 204-465-2 | CAS number: 121-33-5
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No details on study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- No information
- Author:
- OPDYKE DLJ
- Year:
- 1 977
- Bibliographic source:
- Food Cosmet Toxicol, 15(6), 633-638
- Reference Type:
- publication
- Title:
- No information
- Author:
- STRAND LP, SCHELINE RR
- Year:
- 1 975
- Bibliographic source:
- Xenobiotica, 5(1), 49-63
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- Vanillin
- EC Number:
- 204-465-2
- EC Name:
- Vanillin
- Cas Number:
- 121-33-5
- Molecular formula:
- C8H8O3
- IUPAC Name:
- 1-butoxypropan-2-ol
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on exposure:
- A single oral administration to rats of 100 mg/kg bw resulted in the urinary excretion of most of its metabolites within 24 hours, mainly as
glucuronide and/or sulphate conjugates, although the acids formed were also excreted free and as their glycine conjugates. - Duration and frequency of treatment / exposure:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
100 mg/kg bw
- No. of animals per sex per dose / concentration:
- no data
- Control animals:
- not specified
Results and discussion
Metabolite characterisation studies
- Details on metabolites:
- In 48 hours, 94% of the dose had been excreted, in the following proportions:
7% vanillin, 47% vanillic acid, 19% vanillyl alcohol, 10% vanilloylglycine, 8% catechol, 2% 4-methylcatechol, 0.6% 4-methylguaiacol, and 0.5% guaiacol.
No metabolites were found in the urine collected 48-96 hours after dosing.
Any other information on results incl. tables
The conversion of vanillin to vanillic acid was demonstrated in human and rat liver cells in culture (Discher & Brisse, 1966).
An early study found only traces amounts of vanillin in the urine of rabbits given 2g/day orally (about 1g/kg bw/day), the vanillin being conjugated with sulfuric acid. Most of the dose was oxidized to vanillic acid, and this too was excreted as ethereal sulfate conjugate (Preusse, 1880).
Applicant's summary and conclusion
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