Registration Dossier
Registration Dossier
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EC number: 273-727-6 | CAS number: 69012-27-7 By-product of chromium refining containing oxides of aluminum, magnesium and silicon.
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
No fertility tests have been performed with FeCr-slag. The amorphous glass phase of the slag consists of practically insoluble silicates, and therefore these types of silicates are useful for read-across.
One dominal lethal assay done with Ca-silicate does not indicate any reprotoxicity. No indications of fertility effects caused by chromium have been found.
Short description of key information:
No data are available on fertility effects caused by FeCr-slag. No guideline studies were either found for other silicates or chromium. Silicates are widely used as food additives (approved by EFSA). Based on the lack of systemic effects in repeated dose toxicity studies, the silicates can be regarded as practically non-toxic. Therefore it is very unlikely that FeCr-slag would cause any fertility effects
Effects on developmental toxicity
Description of key information
FeCr-slag has not been tested for developmental toxicity/teratogenicity. The amorphous glass phase of the slag consists of practically insoluble silicates, and these types of silicates are useful for read-across. Ca-silicate and Na-Al-silicate did not cause developmental toxicity/teratogenicitywhen tested in various animal species. Based on read-across to these silicates, and the lack of general systemic effects caused by silicates, there are no indications of potential risks of developmental toxicity to be induced by FeCr-slag.
Effect on developmental toxicity: via oral route
- Dose descriptor:
- NOAEL
- 1 600 mg/kg bw/day
Justification for classification or non-classification
No classification is suggested.
FeCr-slag has not been tested for toxicity to reproduction, but based on the general non-toxic nature of the substance, and read-across from limited studies with supporting substances, FeCr-slag is not likely to cause any fertility or developmental toxicity effects. No further testing is needed.
Additional information
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