Registration Dossier
Registration Dossier
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EC number: 273-727-6 | CAS number: 69012-27-7 By-product of chromium refining containing oxides of aluminum, magnesium and silicon.
Epidemiological data
Administrative data
- Endpoint:
- epidemiological data
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Dtech
Data source
Reference
- Reference Type:
- other: evaluation
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
- Study type:
- other: evaluation of the Health Council of the Netherlands
- Endpoint addressed:
- repeated dose toxicity: inhalation
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- evaluation of an authoritative instituition
- GLP compliance:
- no
Test material
- Reference substance name:
- Perlite
- EC Number:
- 603-442-8
- IUPAC Name:
- Perlite
- Reference substance name:
- 93763-70-3
- EC Number:
- 618-970-4
- Cas Number:
- 93763-70-3
- IUPAC Name:
- 93763-70-3
Constituent 1
Constituent 2
Method
- Type of population:
- occupational
- Ethical approval:
- not specified
Results and discussion
- Results:
- In 3 long-term occupational studies in the USA, conducted in the period 1972-1983 on groups of 450, 117, and 152 workers, no evidence of a relationship between working in the perlite industry and the development of lung fibrosis (pneumoconiosis) was found. Tests included chest radiography and lung function parameters FVC and FEV1. No data on personal air exposures were reported, but workplace monitoring in the plants showed that airborne concentrations were close to the nuisance dust level of 10 mg/m3. No data were provided on the percentage of quartz in the per
Applicant's summary and conclusion
- Conclusions:
- No evidence of a relationship between working in the perlite industry and the development of lung fibrosis (pneumoconiosis) has been found.
- Executive summary:
In 3 long-term occupational studies in the USA, conducted in the period 1972-1983 on groups of 450, 117, and 152 workers, no evidence of a relationship between working in the perlite industry and the development of lung fibrosis (pneumoconiosis) was found. Tests included chest radiography and lung function parameters FVC and FEV1. No data on personal air exposures were reported, but workplace monitoring in the plants showed that airborne concentrations were close to the nuisance dust level of 10 mg/m3. No data were provided on the percentage of quartz in the perlite.
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