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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable study report wich meets basic scientific principles.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1958
Report date:
1958

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Acrylic acid
EC Number:
201-177-9
EC Name:
Acrylic acid
Cas Number:
79-10-7
Molecular formula:
C3H4O2
IUPAC Name:
acrylic acid
Details on test material:
- Name of test material (as cited in study report): Acrylic acid, pure
- Analytical purity: no data, no stabilizer

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: Sodium chloride (0.9%)
Doses:
20, 79, 316, 1260, 2040, 3160, 5010 mg/kg bw
No. of animals per sex per dose:
1 - 5 per dose
Control animals:
no

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 1 500 mg/kg bw
Mortality:
LD50: approx. 1500 mg/kg bw. At doses of up to 316 mg/kg bw, no mortalities occured.
Clinical signs:
other: Signs of toxicity were unspecific after administration of Acrylic acid by gavage: abdominal position.
Gross pathology:
No necropsy was performed.

Any other information on results incl. tables

Mortality

Dead/Treated

Dose (mg/kg bw)

24 h

48 h

7 d

20

0/1

0/1

0/1

79

0/1

0/1

0/1

316

0/1

0/1

0/1

1260

1/4

1/4

1/4

2040

3/5

3/5

4/5

3160

5/5

5/5

5/5

5010

1/1

1/1

1/1

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
A LD50 of ~1500 mg/kg bw was found for acrylic acid when administered orally to rats.