2-(4-methylphenoxy)-N-(1H-pyrazol-3-yl)-N-[(thiophen-2-yl)methyl]acetamide

Flammability

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

flammable solids

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Experimental dates: 24 November 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

The study was conducted according to an internationally recognized method, and under GLP. No deviation was reported. The test substance is adequately characterised. Therefore full validation applies.

Qualifier:

according to guideline

Guideline:

UN Manual of Tests and Criteria: Test N.1 (Test method for readily combustible solids)

Version / remarks:

UN MTC rev.6, 2015

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

Inspection 20-21 June 2017, signed on 04 September 2017

Specific details on test material used for the study:

Storage conditions: Ambient temperature (10 °C to 30 °C) in original glass bottle.
The sample was tested as received (moisture content not checked). No further preliminary treatment such as drying or milling was performed.

Key result

Test procedure:

burning rate test: preliminary screening test

Remarks on result:

substance does not ignite and propagate combustion either by burning with flame or smouldering along 200 mm of the powder train within the 2 minutes test period

The test item melted, but could not be ignited with a flame.

The performance of the main test was not necessary.

Interpretation of results:

not classified based on GHS criteria

Remarks:

GHS and EU-CLP criteria not met

Conclusions:

The test item is NOT classified as a flammable solid according to Regulation (EC) N°1272/2008 (CLP) criteria.

Executive summary:

The solid test substance was tested for its flammable properties, according to UN MTC N1 guideline, and under GLP.

During the preliminary assay, the item could not be ignited within the 2-min duration of application of the flame. Therefore no main test was performed.

Reference 2

Endpoint:

pyrophoric solids

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is known to be stable in contact with air at room temperature for prolonged periods of time (days) and hence, the classification procedure does not need to be applied

the study does not need to be conducted because the organic substance does not contain metals or metalloids and hence, the classification procedure does not need to be applied

Justification for type of information:

JUSTIFICATION FOR DATA WAIVING
In accordance with section 1 of REACh Annex XI, study for pyrophoric properties is deemed unnecessary based on the chemical structure that does not fall into critical categories described in ECHA guidance (e.g. no alkali metal, phosporous element, Grignard reagent, metal organic substances...), and based on the experience in handling, testing and use of the substance.
The hazard class does not apply.

Reference 3

Endpoint:

substances / mixtures which in contact with water emit flammable gases

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the organic substance does not contain metals or metalloids and hence, the classification procedure does not need to be applied

the study does not need to be conducted because the experience in production or handling shows that the substance does not react with water, e.g. the substance is manufactured with water or washed with water

the study does not need to be conducted because the substance is known to be soluble in water to form a stable mixture

Justification for type of information:

JUSTIFICATION FOR DATA WAIVING
In accordance with section 1 of REACh Annex XI, study for flammability if contact with water is deemed unnecessary based on the chemical structure that does not fall into critical categories described in ECHA guidance (e.g. no alkali metal, phosporous element, Grignard reagent, metal organic substances...), and based on the experience in handling, testing and use of the substance. In particular, in Water solubility testing presented under IUCLID Section 4.8, though the substance is of low solubility, no particular reaction, hazardous or not, was observed when mixing.
The hazard class does not apply.

Reason / purpose for cross-reference:

data waiving: supporting information

Reference 4

Endpoint:

self-heating substances / mixtures

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is completely molten at 160°C

Justification for type of information:

JUSTIFICATION FOR DATA WAIVING
According to the Guidance on the Application of the CLP Criteria, v5.0 of July 2017:
"the phenomenon of self-heating applies only to solids. The surface of liquids is not large enough for reaction with air and the test method (UN N4) is not applicable to liquids. Therefore liquids are not classified as self-heating…
Substances or mixtures with a low melting point (< 160 °C) should not be considered for classification in this class since the melting process is endothermic and the substance-air surface is drastically reduced. However, this criterion is only applicable if the substance or mixture is completely molten up to this temperature."
Considering that the substance has a melting point of 117.6°C (see IU Section 4.2) the test is considered as NOT necessary.
The hazard class does not apply.

Reason / purpose for cross-reference:

data waiving: supporting information

Description of key information

No ignition in contact with a flame: not a flammable solid (CLP/GHS).

Not pyrophoric. No release of flammable gases if contact with water. No self-heating anticipated. (waived)

Key value for chemical safety assessment

Flammability:

not classified

Additional information

A fully reliable, GLP, experimental study is presented under point 4.13 for flammability of solids. It is considered as a key study.

Based on the chemical structure and experience, no flammable properties are anticipated if contact with air or water, or no self-heating as a low melting solid, therefore studies were deemed unnecessary.

Justification for classification or non-classification

According to Regulation (EC) No.1272/2008 (CLP) and UN Globally Harmonised System (GHS) criteria, the substance failed to ignite in the UN N1 preliminary test, therefore the substance is NOT classified as a flammable solid.