2-(4-methylphenoxy)-N-(1H-pyrazol-3-yl)-N-[(thiophen-2-yl)methyl]acetamide

Surface tension

Link to relevant study record(s)

Reference

Endpoint:

surface tension

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Experimental dates: 11-13 December 2017

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

The study was conducted according to an internationally recognized method, and under GLP. Unplanned deviation on test concentration was reported. The test substance is adequately characterised. Therefore validation applies with restrictions.

Reason / purpose for cross-reference:

reference to other study

Qualifier:

according to guideline

Guideline:

OECD Guideline 115 (Surface Tension of Aqueous Solutions)

Version / remarks:

1995

Deviations:

yes

Remarks:

test concentration

Qualifier:

according to guideline

Guideline:

EU Method A.5 (Surface Tension)

Version / remarks:

Regulation (EC) No. 440/2008

Deviations:

yes

Remarks:

test concentration

GLP compliance:

yes (incl. QA statement)

Remarks:

Inspection 20-21 June 2017, signed on 04 September 2017

Type of method:

OECD harmonised ring method

Specific details on test material used for the study:

Storage conditions: Ambient temperature (10 °C to 30 °C) in original glass bottle.
The sample was tested as received. No further preliminary treatment such as drying or milling was performed.

Key result

Surface tension:

ca. 69.5 mN/m

Temp.:

20 °C

Conc.:

10.7 mg/L

Remarks on result:

other: maximum limit value for concentration (<10.7mg/L)

Measurement	1	2	3	4	5	6
Time (s)	276	398	519	641	762	884
s(mN/m) uncorrected	74.93	75.11	75.05	74.99	74.95	74.91
s(mN/m) corrected according to Zuidema and Waters	69.66	69.59	69.54	69.47	69.43	69.40

Conclusions:

According to EU A5 criteria, as the result is above the threshold value of 60 mN/m, the substance is NOT considered to have surface-active potential under the experimental conditions.

Executive summary:

The surface tension of the test substance was measured under GLP according to OECD 115/EU A5 guidelines, ring method, at 90% of the observed saturation solubility.

Mass calibration was performed.

Six measurements were recorded at steady state (+/- 0.1 mN/m) and values were corrected according to Zuidema and Waters factor.

The mean surface tension of the test substance is ca 69.5 mN/m, at 20°C, and < 10.7 mg/L.

Description of key information

Surface tension = ca 69.5 mN/m, at 90% observed saturation (i.e. < 10.7 mg/L), and 20°C.

According to EU A5 criteria, as the result is above the threshold value of 60 mN/m, the substance is NOT considered to have surface-active potential under the experimental conditions.

Key value for chemical safety assessment

Surface tension:

69.5

Additional information

A reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. Despite restrictions due to deviation on test concentration, it is considered as a key study, and the result is retained as key value.