Registration Dossier
Registration Dossier
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EC number: 200-464-6 | CAS number: 60-24-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions. Restriction: No data about the TS; short exposure time.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- Draize Test (modified 1964)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-mercaptoethanol
- EC Number:
- 200-464-6
- EC Name:
- 2-mercaptoethanol
- Cas Number:
- 60-24-2
- Molecular formula:
- C2H6OS
- IUPAC Name:
- 2-sulfanylethan-1-ol
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye of the same animal
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 35 d
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- rinsed after ca. 4 seconds
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Time point:
- 24 h
- Score:
- 33.6
- Max. score:
- 110
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
Any other information on results incl. tables
No vocalization upon dosing. None of the rabbits died at the end of the day 35 observation period. All rabbits showed an increase in body weight gain. The maximum average eye irritation score according to the Draize method was 33.6 at 24 hours (total max. score 110). 1 female showed hair loss around the right eye.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information
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