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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: early study report; short study description

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1964
Report Date:
1964
Title:
No information
Author:
BASF Corp. (1992). Initial submission: 2-mercaptoethanol: toxicology report with cover letter dated 052692. OTS0539597, Doc. I.D: 88-920003009, 27 May 1992

Materials and methods

Principles of method if other than guideline:
BASF-internal standard
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Controls:
other: untreated skin of the same animal
Amount / concentration applied:
undiluted
Duration of treatment / exposure:
20 hour(s)
Observation period:
8 days
Number of animals:
2

Results and discussion

In vivo

Results
Irritation parameter:
other:
Reversibility:
not specified
Remarks on result:
positive indication of irritation

Any other information on results incl. tables

Rabbits died during exposure period; 
local effects: grey-yellow necrosis of the skin.

Applicant's summary and conclusion

Interpretation of results:
corrosive