Registration Dossier
Registration Dossier
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EC number: 200-464-6 | CAS number: 60-24-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: early study report; short study description
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
- Report date:
- 1964
- Title:
- No information
- Author:
- BASF Corp. (1992). Initial submission: 2-mercaptoethanol: toxicology report with cover letter dated 052692. OTS0539597, Doc. I.D: 88-920003009, 27 May 1992
Materials and methods
- Principles of method if other than guideline:
- BASF-internal standard
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-mercaptoethanol
- EC Number:
- 200-464-6
- EC Name:
- 2-mercaptoethanol
- Cas Number:
- 60-24-2
- Molecular formula:
- C2H6OS
- IUPAC Name:
- 2-sulfanylethan-1-ol
Constituent 1
Test animals
- Species:
- rabbit
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Controls:
- other: untreated skin of the same animal
- Amount / concentration applied:
- undiluted
- Duration of treatment / exposure:
- 20 hour(s)
- Observation period:
- 8 days
- Number of animals:
- 2
Results and discussion
In vivo
Results
- Irritation parameter:
- other:
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
Any other information on results incl. tables
Rabbits died during exposure period;
local effects: grey-yellow necrosis of the skin.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
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