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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: early study report; only short study description

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1964
Report date:
1964

Materials and methods

Principles of method if other than guideline:
according to BASF-internal standards
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-mercaptoethanol
EC Number:
200-464-6
EC Name:
2-mercaptoethanol
Cas Number:
60-24-2
Molecular formula:
C2H6OS
IUPAC Name:
2-sulfanylethan-1-ol

Test animals

Species:
rat
Strain:
other: Heigl
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
200, 400, 800, 1600 cmm/kg
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
Concentrations given were 2 - 20% in water; observation period: 7 days

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LD50
Effect level:
336 mg/kg bw
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 300 other: cmm/kg
Remarks on result:
other: original value
Mortality:
1600 cmm/kg: 5/5 after 7 days (20% concentration); 800 cmm/kg: 5/5 after 7 days (4% concentration); 400 cmm/kg: 4/5 after 7 days (4% concentration), 200 cmm/kg: 1/5 after 7 days (2% concentration)
Clinical signs:
other: Jumping, running, rolling behavior; tonic-clonic seizure; cyanosis; recovery after 4-6 d.
Gross pathology:
Sacrificed animals: nothing abnormal detected.

Applicant's summary and conclusion