Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 200-464-6 | CAS number: 60-24-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- THE METABOLISM OF MERCAPTOETHANOL BY THE LIVING RAT
- Author:
- G. Federici, G. Ricci, S. Dupre, A. Antonucci, D. Cavallini
- Year:
- 1 976
- Bibliographic source:
- Biochemistry and Experimental Biology, 12, 341-345
Materials and methods
- Objective of study:
- absorption
- excretion
- metabolism
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- investigation on the possible role of mercaptoethanol as a precursor of other sulfur·containing compounds in the living animal
- GLP compliance:
- no
Test material
- Radiolabelling:
- yes
Test animals
- Species:
- rat
- Strain:
- Wistar
- Details on species / strain selection:
- no data
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Details on exposure:
- single administration of 0.4 mCi of 35S-mercaptoethanol
- Duration and frequency of treatment / exposure:
- single administration
Doses / concentrations
- Dose / conc.:
- 0.4 other: mCi
- No. of animals per sex per dose / concentration:
- 2
- Control animals:
- no
- Positive control reference chemical:
- not applicable
- Details on study design:
- Male rats of the Wistar strain (150-200 g) received 35 S·Mercaptoethanol (0.4 mCi/mmol) by intraperitoneal injection. They were kept in metabolic cages on a conventional complete diet.
- Details on dosing and sampling:
- Urine was collected daily, separated from feces, in a vessel containing few drops of concentrated HCI and stored frozen unless analyzed immediately.
- Statistics:
- not applicable
Results and discussion
Any other information on results incl. tables
Total radioactivity registered in the urine after injection of 0.4 mCi of 35S-mercaptoethanol was 91% in the first day and 8% in the second day. Within three days almost all the radioactivity injected was excreted in the urine. The results clearly indicate that mercaptoethanol is largely metabolized by the living rat up to the conversion into sulfate. A number of other metabolites have also been detected but not identified. Electrophoretic and chromatographic analysis, in various conditions, led to the identification of sulphate as a major component and small amount of isethionic acid. The presence of mixed disulfides of injected mercaptoethanol with naturally occurring sulphydryl compounds present in the urine and the presence of radioactive S-sulfonates (Bunte salts) should be excluded by the negative results obtained by oxidation and reduction of the urine. The absence of mixed disulfides and of Bunte salts has been confirmed by treating the urine with an excess of unlabelled mercaptoethanol. HCl hydrolysis indicated that none of the peaks should be imputable to a sulfate ester.
Applicant's summary and conclusion
- Conclusions:
- 35 S-Mercaptoethanol injected into living rats is rapidly metabolized, giving raise to at least five compounds, which are excreted in the urine. After two days 99% of injected radioactivity is recovered. Electrophoretic and chromatographic analysis, in various conditions, led to the identification of sulphate as a major component and small amount of isethionic acid. The remaining metabolites were not identified.
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