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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Study period:
48 hours - 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
Deviations:
not specified
GLP compliance:
no
Remarks:
This testing was sourced outside of the EU in the USA where GLP is not necessarily required for this test.
Specific details on test material used for the study:
Assay: 10.1% [Mono] 2-(Perfluorohexyl)ethyl-Phosphate ammonium salt, 18.6% [Di] 2-(Perfluorohexyl)ethyl-Phosphate ammonium salt
Chemical State and Description: Beige to tan emulsion
Lot Number: W17033003
Storage Conditions: Ambient
Analytical monitoring:
no
Vehicle:
no
Details on test solutions:
Nominal test concentrations were control, 2.86, 14.3, 71.4, and 357 mg form./L, which corresponds to control, 0.800, 4.00, 20.0, and 100 mg a.i./L.
Since no analytical measurements were conducted, the results are based on the nominal test concentrations.
Test organisms (species):
Daphnia magna
Test type:
other: static-renewal
Water media type:
other: Hard Water (blended spring and reverse osmosis)
Total exposure duration:
48 h
Test temperature:
19.9C - 20.2C
pH:
7.8 - 7.9
Dissolved oxygen:
8.9 mg/L (measured in controls)
Key result
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
mobility
Key result
Duration:
48 h
Dose descriptor:
LOEC
Effect conc.:
ca. 4 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
mobility
Key result
Duration:
48 h
Dose descriptor:
NOEC
Effect conc.:
ca. 0.8 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
mobility
Details on results:
Immobilization occurred in the two highest test levels. Sublethal effects were observed in the three highest test levels. Daphnids were normal in the control and the lowest test level.
Validity criteria fulfilled:
yes
Conclusions:
The 48-hour EC50 was >357 mg formulation (> 100 mg a.i.)/L. Based on immobilization and sublethal effects, the 48-hour NOEC was 2.86 mg formulation (0.800 mg a.i.)/L and the 48-hour LOEC was 14.3 mg formulation (4.00 mg a.i.)/L.

Description of key information

The 48-hour EC50was >357 mg formulation (> 100 mg a.i.)/L. Based on immobilization and sublethal effects, the 48-hour NOEC was 2.86 mg formulation (0.800 mg a.i.)/L and the 48-hour LOEC was 14.3 mg formulation (4.00 mg a.i.)/L.  

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
100 mg/L

Additional information