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EC number: 203-389-7 | CAS number: 106-36-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study methodology followed was equivalent or similar to OECD TG 403 and there is no mention in the report on the status of compliance with the Principles of Good Laboratory Practice (GLP).
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- not specified
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Propyl propionate
- EC Number:
- 203-389-7
- EC Name:
- Propyl propionate
- Cas Number:
- 106-36-5
- Molecular formula:
- C6H12O2
- IUPAC Name:
- propyl propanoate
- Details on test material:
- - Name of test material (as cited in study report): n-propyl propionate
- Physical state: colorless, transparent, low viscosity liquid
- Analytical purity: 100%
- Lot/batch No.: 51-535; 52-19 (15RLRX51)
- Storage condition of test material: room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: assumed to be in-house
- Age at study initiation: young adults
- Weight at study initiation: 200-300 grams
- Fasting period before study: yes
- Housing: assumed to be group housed
- Diet: ad libitum, appropriate commercial diet, except during the period of fasting
- Water: municipal water, ad libitum
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- The vapor was produced by enclosing approximately 100 g of the test material in a sealed 100 to 152-liter animal chamber for approximately 18 hours (static conditions). A mixing fan periodically agitated the chamber atmosphere to aid in distribution of the vapor. Oxygen was added, as needed, for static exposures to maintain chamber oxygen content of approximately 20%.
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 6 h
- Concentrations:
- Saturated vapor concentration (conversion value of 14031.58 ppm or 66 mg/l, based on vapor pressure of 10.664 mm Hg at 20 °C and molecular weight of 116.16)
- No. of animals per sex per dose:
- 5 males + 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:observed daily and body weights recorded weekly
- Necropsy of survivors performed: yes - Statistics:
- LD50's and the estimated LD50 slopes were calculated by the moving average method
Results and discussion
- Preliminary study:
- not applicable
Effect levels
- Sex:
- male/female
- Dose descriptor:
- other: LT50 (lethal time 50)
- Effect level:
- other: Saturated vapor concentration
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Remarks on result:
- other: Saturated vapor concentration (conversion value of 14031.58 ppm or 66 mg/l, based on vapor pressure of 10.664 mm Hg at 20 °C and molecular weight of 116.16)
- Mortality:
- Exposure to a statically-generated, substantially saturated vapor produced deaths of 2 of 5 female rats within one day, while no mortality was noted in the male rats.
- Clinical signs:
- other: Hypoactivity, a reduced breathing rate and ataxia were evident during or following exposure.
- Body weight:
- Body weight gain was noted in all the animals
- Gross pathology:
- Necropsy revealed dark red lungs in the rats that died, while the survivors had no remarkable gross pathologic findings.
- Other findings:
- None
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of the study and based on the Guidance to Regulation (EC) No. 1272/2008 on Classification, Labelling and Packaging of substances and mixtures, n-propyl propionate will not be classified for acute inhalation toxicity.
- Executive summary:
In this study, Sprague-Dawley albino rats, weighing between 200 and 300 g, were exposed to substantially saturated vapor for 6 hours. The vapor was produced by enclosing approximately 100 g of the test material in a sealed 100 to 152-liter animal chamber for approximately 18 hours (static conditions). A mixing fan periodically agitated the chamber atmosphere to aid in distribution of the vapor. Oxygen was added, as needed, for static exposures to maintain chamber oxygen content of approximately 20%.
Exposure to a statically-generated, substantially saturated vapor (conversion value of 14031.58 ppm or 66 mg/l, based on vapor pressure of 10.664 mm Hg at 20 °C and molecular weight of 116.16) produced deaths of 2 of 5 female rats within one day, while no mortality was noted in the male rats. Hypoactivity, a reduced breathing rate and ataxia were evident during or following exposure. Survivors recovered after one day. Under the conditions of the study and based on the Guidance to Regulation (EC) No. 1272/2008 on Classification, Labelling and Packaging of substances and mixtures, n-propyl propionate will not be classified for acute inhalation toxicity.
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