Registration Dossier
Registration Dossier
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EC number: 500-039-8 | CAS number: 25322-69-4 1 - 4.5 moles propoxylated
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
No experimental data are available for ‘propane-1,2-diol, propoxylated’l. However, for the structural analogues and constituents mono-, di- and tripropylene glycol data are available. Based on the lowest value, the 3h-NOEC of 1000 mg/L (for tripropylene glycol), it can be assumed that the 3h-NOEC for ‘propane-1,2-diol, propoxylated’ is 1000 mg/L.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 1 000 mg/L
Additional information
Monopropylene glycol:
Reliable test data are available for toxicity to microorganisms. In a near guideline test with Pseudomonas putida an 18-h NOEC of 20,000 mg/l was determined in a growth inhibition test. Nominal values were reported (The Dow Chemical Company, 1982).
Dipropylene glycol:
Reliable test data are available for toxicity to microorganisms. In a GLP compliant guideline test with Pseudomonas putida an 18-h EC10 of >1000 mg/l was determined (NATEC Institut fuer naturwissenschaftlich-technische Dienste GmbH, 1992).
Tripropylene glycol:
One GLP compliant guideline study (OECD 209) is available for tripropylene glycol. No significant effects were observed at concentrations of 10, 32, 100, 320 and 1000 mg/L.
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