Propane-1,2-diol, propoxylated

Endpoint summary

Additional information

No data is available for ‘propane-1,2-diol, propoxylated’. Comparing the available aquatic toxicity data, the QSAR information and the constitution of ‘propane-1,2-diol, propoxylated’, it seems likely that the aquatic toxicity is expected to be similar to di- and tripropylene glycol. As from the QSAR data it is observed that dipropylene glycol has the tendency to be more toxic than tripropylene glycol in any case the lowest effect concentration of the two substances will be considered. Consequently, the results for di and tripropylene glycol were taken for read across and the lowest effect concentration was considered.

Short term toxicity to fish:

No experimental data are available for ‘propane-1,2-diol, propoxylated’. Based on the 96-h LC50 of the structurally related analogue and constituent tripropylene glycol (> 1000 mg/L), it can be assumed that the 96-h LC50 of ‘propane-1,2-diol, propoxylated’ is > 1000 mg/L. This is supported by calculations with the ECOSAR QSAR which indicate a 96h-LC50 values for the components well in excess of this.

 

Long-term toxicity to fish:

Long-term exposure of fish is not considered relevant as the substance is biodegradable. Furthermore, the short-term toxicity test shows very low toxicity to fish. As the QSAR for long-term toxicity to fish is high (30-d ChV is predicted to be in the range 1800 -2100mg/L), chronic toxicity to fish is not expected. Therefore, the long-term toxicity test with fish does not seem necessary to perform.

 

Short-term toxicity to aquatic invertebrates:

No experimental data are available for ‘propane-1,2-diol, propoxylated’. However, for the structural analogues and constituents mono-, di- and tripropylene glycol data are available. Based on the lowest 48h-EC50 of >100 mg/L (for dipropylene glycol), it can be assumed that the 48h-EC50 for ‘propane-1,2-diol, propoxylated’ is > 100 mg/L. This is supported by calculations with ECOSAR v1.11 which indicate a 48h-EC50 in the range 11000 -12500 mg/l.

 

Long-term toxicity to aquatic invertebrates:

Long-term exposure of aquatic invertebrates is not considered relevant as the substance is ready biodegradable. Furthermore, the long-term toxicity test with the structural analogues mono- and tripropylene glycol show very low long term toxicity to aquatic invertebrates (7d NOEC of the order of 13000 mg/L to Ceriodaphnia duba and 21d-NOEC of > 1000 mg/L to Daphnia magna, respectively). Based on these results, it can be assumed that the 21d-NOEC of ‘propane-1,2-diol, propoxylated’ is > 100 mg/L. This is supported by calculations with ECOSAR v1.00 which indicate a 16d-ChV in the range 550 -650mg/L. Therefore, a long-term toxicity test with aquatic invertebrates is not considered necessary.

 

Toxicity to aquatic algae:

No experimental data are available for ‘propane-1,2-diol, propoxylated’. However, for the structural analogues and constituents mono-, di- and tripropylene glycol data are available. Based on the lowest 72h-EC50 of >100 mg/L (for dipropylene glycol), it can be assumed that the 72h-EC50 for ‘propane-1,2-diol, propoxylated’ is > 100 mg/L. This is supported by calculations with ECOSAR v1.00 which indicate a 72h-EC50 value in the range 3000 -4000 mg/L.

 

Toxicity to micro-organisms:

No experimental data are available for ‘propane-1,2-diol, propoxylated’. However, for the structural analogues and constituents mono-, di- and tripropylene glycol data are available. Based on the lowest value, the 3h-NOEC of 1000 mg/L (for tripropylene glycol), it can be assumed that the 3h-NOEC for ‘propane-1,2-diol, propoxylated’ is 1000 mg/L.