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EC number: 931-515-7
CAS number: 1334422-18-2
18 (25% in mineral oil) was tested for the potential to induce contact
upon repeated application under semi-occlusive conditions. Sodium lauryl
sulfate (0.1% in distilled water) was used for comparison. The test
conditions were appropriate for this study type. Reactions were scored
with a numerical and letter grade to indicate severity and type of
reaction. Only two of the thirty-one subjects exhibited mild erythema
(which was resolved within 24 hours) during the induction phase compared
to nine subjects exhibiting mild to moderate erythema after exposure to
0.1% sodium lauryl sulfate. Results indicate that Neodene® 18 does not
cause clinical irritation or sensitization in human subjects.
study received a Klimisch score of 2 and is classified as reliable with
restrictions because while there is no statement regarding whether this
study was conducted according to GLP or equivalent, the study protocol
was provided and was cited as adapted from the Draize test. Further, the
results were well-documented and scientifically acceptable.
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