Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
TETRAHYDRO-PAPAVERINE AND HOMODIHYDRO-PAPAVERINE ON BLOOD PRESSURE Effect Of
Year:
1964
Bibliographic source:
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 200

Materials and methods

Principles of method if other than guideline:
method not available
GLP compliance:
not specified

Test material

1
Chemical structure
Reference substance name:
1-(3,4-dimethoxybenzyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinolinium chloride
EC Number:
229-213-9
EC Name:
1-(3,4-dimethoxybenzyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinolinium chloride
Cas Number:
6429-04-5
Molecular formula:
C20H25NO4.ClH
IUPAC Name:
1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-ium chloride
Test material form:
solid: particulate/powder

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
700 mg/kg bw

Applicant's summary and conclusion