Registration Dossier

Guidance on Safe Use

Guidance on Safe Use

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Administrative data

First-aid measures

General information: Remove from exposure. Remove contaminated clothing and shoes.
Consult a physician if an irritation develops or persists.

First aid measures:
After inhalation: Remove to fresh air and monitor breathing. If breathing becoming difficult, give oxygen and consult a physician. If breathing stops, give artificial respiration and consult a physician.
After skin contact: Wash the effected area with copious amount of water for at least 15 minutes. Consult a physician.
After eye contact: Flush with plenty of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers.
Consult immediately with a physician.
After swallowing: Wash out the mouth with water, if the person is conscious and consult a physician.

Information to physicians: Special antidote is not known. Treat sustainably and symptomatically.

Fire-fighting measures

Combustible solid. Electrostatically chargeable powder. Dust/air mixture may ignite or explode. Take measures against electrostatic discharges.

Suitable extinguishing media: Water spray, carbon dioxide, dry chemical powder or foam. Use water spray for cooling containers.
Protective equipment: Self-contained breathing apparatus and protecting clothes.
In event of fire: Formation of CO, CO2, NOx, HCl is possible.

Accidental release measures

Do not let to flow into the environment. In case of spill collect the material carefully into labelled container for disposal.
Avoid dusting. Use personal protective equipment. The personal protective equipments are tightly fitting, chemical resistant safety googles, chemical resistant gloves and dust mask (FFP3) or gas mask with A2B2P3 filter cartridge.
Dispose as hazardous waste. Incineration is recommended.

Handling and storage

Closed technology recommended to avoid exposure to material and to ensure rigorous containment at all process step.
Isolator with glove box and HEPA filters recommended for powder transport and sampling.
In case of accident or incident for precaution of exposure use combined personal protective equipments:
respiratory protection hood with face shield and P3 filter, protective clothes, protective gloves.
Electrostatically chargeable, combustible powder. Avoid dusting. Avoid generation of sparks.
Store in well closed containers in a cool and well ventilated place. Protect from light, moisture and heat.
Warning! The toxicological profile of substance is not completely defined!

Transport information

Land transport (ADR/RID)

UN number:
Not a dangerous good.

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Inland waterway transport (ADN(R))

UN number:
Not a dangerous good.
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Marine transport (IMDG)

UN number:
Not a dangerous good.
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Air transport ICAO/IATA

UN number:
Not a dangerous good.
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Miscellaneous.
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Exposure controls / personal protection

As a general rule, when handling avoid all contact and inhalation of dust, mists, and/or vapours associated with the material.
Wear protective clothing, gloves and eye/face protection. Ensure adequate general and local ventilation.
Handle under extracting hood in the laboratories. Do not breathe dust.
In case of possible exposure respiratory protection is needed. (Gas mask with P3 filter).

Closed technology recommended to avoid exposure to material. For precaution of exposure use combined personal protective equipments
(respiratory protection hood with face shield, protective clothes, protective gloves).

Industrial hygiene: Wash hands and face with plentiful water after working with the substance. Remove contaminated clothing. Wash before reuse.
It is forbidden to eat, drink, store food and smoke at the workplace.
Safety eyewash and emergency shower needed.

Measures applied by the registrant during use of the intermediate:
- The reaction carried out in a fully contained system,using fixed installations (pipes, vessels) and powder transport system (PTS) with glove box for solid substance handling. The system ensure the rigorous containment at all process step (i.e. loading the reactor, chemical transformation)
-PPE use only in case of accidents, incidents, maintenance and cleaning activities. PPE specified in the permit-to-work system.
- The reaction vessel, the centrifuge and the other vessels are connected via fix pipes.
- All pumps, valves are fully sealed
- Parameters (temperature and pressure) and processes are 24/7 controlled by qualified operators
-The maintenance is part of a documented permit-to-work system requiring 1. cleaning procedure before the maintenance 2. supervisor authorization 3. constant supervision
- Personnel are trained and fully supervised
- Personnel are trained what to do in case of accidents and incidents (including the use of PPE) to minimize risk to human and the environment resulting from unexpected release of the substance. PPE include respirator, gloves, body protection. The training is documented.
- Workers use eye protection during all operations (as a precautionary measure)

Warning! The toxicological profile of substance is not completely defined!

Stability and reactivity

Stable in normal conditions.
Organic substance. Can be reactive with strong oxidisers.

Disposal considerations

Incineration is recommended.