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Melting point / freezing point

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Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
The study was conducted on 24 February 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
not specified
GLP compliance:
not specified
Remarks:
Study was not conducted under a specific Good Laboratory Practices (GLP) program, this study was conducted following the principles of GLP by experienced and trained personnel using calibrated standards and instrumentation. Relevant SOPs were followed.
Type of method:
differential scanning calorimetry
Specific details on test material used for the study:
Lot/Batch number: 1004R18708
Key result
Melting / freezing pt.:
> 395 - < 396 K

Two sets of measurements were carried out for RD14156 and results are shown the Table. The DSC data indicated one strong endothermal event at 396K. The capillary measurement showed a melting point at 394 K. The results are in agreement with each other in view of the estimated accuracy, and a melting point average is taken at 395K.

Melting point determinations in Kelvin for RD14156.

 Measurement  #1  #2  #3  Average
 DCS  396  395  396  396
 Capillary  395  394  394  394
Conclusions:
Two sets of measurements were carried out for RD14156 and results are shown in Table 2. The DSC data presented in Appendix I indicates one strong endothermal event at 396K. The capillary measurement showed a melting point at 394 K. The results are in agreement with each other in view of the estimated accuracy, and a melting point average is taken at 395K.
Executive summary:

The material under test was analyzed per guidelines set forth in OECD 102. A first set of determinations was carried out by Differential Scanning Calorimetry, using a TA instruments DSC2010 Calorimeter. A second set of determinations was carried out using an Electrothermal IA 9000 capillary melting point apparatus. RD14156 has a melting point of 395K.

Description of key information

Two sets of measurements were carried out for RD14156. The DSC data indicates one strong endothermal event at 396K. The capillary measurement showed a melting point at 394 K. The results are in agreement with each other in view of the estimated accuracy, and a melting point average is taken at 395K.

Melting point determination in Kelvin for RD14156.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
396 K

Additional information