Registration Dossier
Registration Dossier
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EC number: 226-558-7 | CAS number: 5424-01-1
Auto flammability
Administrative data
- Endpoint:
- relative self-ignition temperature (solids)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 February 2013 - 28 March 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study has been performed in accordance with the EC.A16 guideline and complied with the principles of GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.16 (Relative Self-Ignition Temperature for Solids)
- Version / remarks:
- (2008)
- Deviations:
- yes
- Remarks:
- The temperature of the oven was increased to 400°C although the melting temperature of the substance is lower.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3-aminopyrazine-2-carboxylic acid
- EC Number:
- 226-558-7
- EC Name:
- 3-aminopyrazine-2-carboxylic acid
- Cas Number:
- 5424-01-1
- Molecular formula:
- C5H5N3O2
- IUPAC Name:
- 3-aminopyrazine-2-carboxylic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): Amiloride Compound 5
- Description: Tan powder
- Storage condition of test material: In refrigerator (2-8°C) protected from light, desiccated
- Other: Reactive to light, moisture and oxygen
Constituent 1
Results and discussion
Relative self-ignition temperature (solids)
- Remarks on result:
- no self ignition observed under the test conditions
Any other information on results incl. tables
No endothermic or exothermic reaction between 20°C and 400°C. An exothermic effect was observed at an oven temperature of 400.2°C, the test substance reached a temperature of 428.4°C. After the experiment, no test substance was left in the test cube or container that was placed below the cube. It indicated that the test substance was molten and evaporated during the experiment. This is in line with the melting temperature of the substance (206°C:see endpoint 4.2).
Applicant's summary and conclusion
- Conclusions:
- The relative self-ignition test was performed (GLP-compliant study in accordance with EC A.16), not resulting in a temperature at which self-ignition of the substance took place.
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