Registration Dossier
Registration Dossier
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EC number: 251-823-9 | CAS number: 34090-76-1
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No information on guideline available. For details on materials and methods see IUCLID5 dossier.
- GLP compliance:
- no
Test material
- Reference substance name:
- Tetrahydromethylphthalic anhydride
- EC Number:
- 234-290-7
- EC Name:
- Tetrahydromethylphthalic anhydride
- Cas Number:
- 11070-44-3
- IUPAC Name:
- 3a-methyl-3a,4,5,6-tetrahydro-2-benzofuran-1,3-dione
- Details on test material:
- - Name of test material (as cited in study report): HN-2200
- Lot/batch No.: 103
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Donryu
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- no details given
TEST ANIMALS
- Weight at study initiation: 200g
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: undiluted
- Details on exposure:
- no details given
- Doses:
- 0.0336, 0.0403, 0.0483, 0.0579, 0.0834 and 0.100 ml
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: per day
- Necropsy of survivors performed: no - Statistics:
- no details given
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 255 mg/kg bw
- 95% CL:
- > 175 - < 332
- Mortality:
- 0.100 ml/200g: 6/6 (2 days)
0.0834 ml/200g: 4/6 (2days)
0.0695 ml/200g: 3/6 (2 days)
0.0579 ml/200g: 2/6 (2 days)
0.0483 ml/200g: 2/6 (2 days)
0.0403 ml/200g: 2/6
0.0336 ml/200g: 0/6
- Clinical signs:
- under high concentration dose
after 4-5min: calming effects of mobility
after 30 min: respiratory paralysis and death in an abdominal position - Body weight:
- no details given
- Gross pathology:
- no details given
- Other findings:
- no details given
Applicant's summary and conclusion
- Conclusions:
- LD50(Male, mouse, intraperitoneal) = 255 mg/kg
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