Registration Dossier

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
3 (not reliable)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1969
Report Date:
1969

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No information on guideline available. For details on materials and methods see IUCLID5 dossier.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): HN-2200
- Lot/batch No.: 103

Test animals

Species:
rat
Strain:
other: Donryu
Sex:
male
Details on test animals and environmental conditions:
no details given
TEST ANIMALS
- Weight at study initiation: 200g

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: undiluted
Details on exposure:
no details given
Doses:
0.0336, 0.0403, 0.0483, 0.0579, 0.0834 and 0.100 ml
No. of animals per sex per dose:
6
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: per day
- Necropsy of survivors performed: no
Statistics:
no details given

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
255 mg/kg bw
95% CL:
> 175 - < 332
Mortality:
0.100 ml/200g: 6/6 (2 days)
0.0834 ml/200g: 4/6 (2days)
0.0695 ml/200g: 3/6 (2 days)
0.0579 ml/200g: 2/6 (2 days)
0.0483 ml/200g: 2/6 (2 days)
0.0403 ml/200g: 2/6
0.0336 ml/200g: 0/6

Clinical signs:
under high concentration dose
after 4-5min: calming effects of mobility
after 30 min: respiratory paralysis and death in an abdominal position
Body weight:
no details given
Gross pathology:
no details given
Other findings:
no details given

Applicant's summary and conclusion

Conclusions:
LD50(Male, mouse, intraperitoneal) = 255 mg/kg