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EC number: 251-823-9 | CAS number: 34090-76-1
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
The potential of bioaccumulation of tetrahydro-4-methylphthalic anhydride (4-MTHPA) is low.
Key value for chemical safety assessment
- BCF (aquatic species):
- 20.9 dimensionless
Additional information
The log Pow of 1.88 does not indicate thattetrahydro-4 -methylphthalic anhydride (4-MTHPA) might bioaccumulate.
The BCF of 4-MTHPA was, in addition, assessed in a weight of evidence approach by QSAR calculations and read across to related substances..
According to QSAR (BCFBAF ver.3.0), BCF of the test substance (4 -MTHPA) is 8.08 L/kg wet weight.
As the substance is rapidly hydrolysed to the corresponding dicarboxylic acid, a QSAR calculation of the BCF of the hydrolysis product of 4 -MTHPA was conducted in addition, giving a value of 3.162 L/kg wet weight.
QSAR estimation of a structural analogue of the test substance, methyltetrahydrophthalic anhydride (MTHPA), results in a BCF in the range of 17.16 -20.9 while that of its hydrolysis product is calculated to be less than 3.2.
Bioaccumulation of the hydrolysis products of two structural analoges of 4 -MTHPA has yielded experimental values as follows:
4 -cyclohexene-1,2 -dicarboxylic acid. (CAS No. 88 -98 -2): < 0.2 (2 mg/l), < 2 (0.2 mg/l).
BCF of 4-methylcyclohexane-1,2-dicarboxylic acid (CAS No.57567 -84 -7): < 0.2 (0.5 mg/l), < 2.4 (0.05 mg/l).
It may therefore be concluded the potential of bioaccumulation of 4 -MTHPA is low.
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