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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (LLNA)
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification

Data source

Reference
Reference Type:
other: Prediction
Title:
Unnamed
Year:
2016

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
QSAR TOOLBOX

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3-Dichloro-2-(2,4-difluoro-phenyl-propan-2-ol
EC Number:
617-842-5
Cas Number:
86386-74-5
Molecular formula:
C9H8Cl2F2O
IUPAC Name:
1,3-Dichloro-2-(2,4-difluoro-phenyl-propan-2-ol
Test material form:
solid: particulate/powder

Results and discussion

In vivo (LLNA)

Results
Key result
Parameter:
EC3
Value:
2.4
Remarks on result:
positive indication of skin sensitisation based on QSAR/QSPR prediction

Applicant's summary and conclusion

Interpretation of results:
Category 1B (indication of skin sensitising potential) based on GHS criteria

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