Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Additional information:

In the human literature, there is no evidence of allergic contact dermatitis to either gasoline or naphtha blending streams. In laboratory animals, neither gasoline nor naphtha blending streams induced dermal sensitization in Buehler tests in guinea pigs.

Migrated from Short description of key information:
Skin sensitization – Not sensitizing in guinea pig (OECD TG 406).

Justification for classification or non-classification

The animal studies were conducted under regulatory guidelines and in accordance with good laboratory practice recommendations.  Thus, the data can be used without restriction for regulatory purposes. There is no need to conduct additional animal testing for these endpoints.