Registration Dossier
Registration Dossier
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EC number: 235-473-4 | CAS number: 12239-15-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database
Data source
Referenceopen allclose all
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity study of 1-Phenyl-3-methyl-5-aminopyrazole(1131-18-6) in rats
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- Chemidplus Database,U.S. National Library of Medicine,2017
- Reference Type:
- review article or handbook
- Title:
- RTECS NUMBER : UQ4990000
- Author:
- RTECS database
- Year:
- 2 017
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances),2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- The acute toxicity study of 3-methyl-1-phenylpyrazol-5-ylamine(1131-18-6) was performed in rat by oral route.
- GLP compliance:
- not specified
- Test type:
- other: no data available
- Limit test:
- no
Test material
- Reference substance name:
- 3-methyl-1-phenylpyrazol-5-ylamine
- EC Number:
- 214-463-3
- EC Name:
- 3-methyl-1-phenylpyrazol-5-ylamine
- Cas Number:
- 1131-18-6
- Molecular formula:
- C10H11N3
- IUPAC Name:
- 3-methyl-1-phenylpyrazol-5-ylamine
- Test material form:
- solid
- Details on test material:
- - Name of test material: 3-methyl-1-phenylpyrazol-5-ylamine
- Molecular formula: C10H11N3
- Molecular weight: 173.21744 g/mole
- Substance type: Organic
- Physical state: Solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: 3-methyl-1-phenylpyrazol-5-ylamine
- Molecular formula: C10H11N3
- Molecular weight: 173.21744 g/mole
- Substance type: Organic
- Physical state: Solid
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 2500 mg/kg
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 500 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50 % mortality observed
- Mortality:
- 50 % mortality was observed in treated rats at 2500 mg/kg bw
- Clinical signs:
- other: Changes in motor activity were observed.
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Conclusions:
- LD50 was considered to be 2500 mg/kg bw,when rat were treated with 3-methyl-1-phenyl-1H-pyrazol-5-amine(1131-18-6) orally.
- Executive summary:
In a acute oral toxicity study, rats were treated with 3-methyl-1-phenyl-1H-pyrazol-5-amine (1131-18-6) in the concentration of 2500 mg/kg bw orally. 50 % mortality was observed in treated rats at 2500 mg/kg bw. Changes in motor activity were observed. Therefore, LD50 was considered to be 2500 mg/kg bw,when rat were treated with 3-methyl-1-phenyl-1H-pyrazol-5-amine (1131-18-6) orally.
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