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Biodegradation in water : screening test:

Biodegradability of test chemical Sodium 4-chloro-3-nitrobenzenesulphonate (CAS no.17691 -19 -9) was estimated by

using OECD QSAR tool box v3.3 by considering six closest read across chemicals with log Kow as primary descriptor. The test chemical 2-aminotoluene-4-sulphonic acid undergoes 0.3% biodegradation by considering BOD as parameter and microrganisms as inoculum in 28 days. On the basis of this percent biodegradability value it can be concluded that test chemical Sodium 4-chloro-3-nitrobenzenesulphonate is not readily biodegradable.

Additional information

Biodegradation in water : screening test:

Various predicted data for the target compoundSodium 4-chloro-3-nitrobenzenesulphonate ( CAS no. 17691 -19 -9) and supporting weight of evidence studies for its read across substance were reviewed for the biodegradation end point which are summarized as below:

 

Biodegradability of test chemical Sodium 4-chloro-3-nitrobenzenesulphonate (CAS no.17691 -19 -9) was estimated by using OECD QSAR tool box v3.3 by considering six closest read across chemicals with log Kow as primary descriptor. The test chemical 2-aminotoluene-4-sulphonic acid undergoes 0.3% biodegradation by considering BOD as parameter and microrganisms as inoculum in 28 days. On the basis of this percent biodegradability value it can be concluded that test chemical Sodium 4-chloro-3-nitrobenzenesulphonate is not readily biodegradable.

 

The above prediction was supported by experimental data summarized in Chemosphere , Vol 28 , pp 2203-2236 1994 for the structurally similar read across substance Sodium [1,1'-biphenyl]-4-sulphonate (2217-82-5).

 

The test chemical Sodium [1,1'-biphenyl]-4-sulphonate when subjected for biodegradation test , showed less then 20% biodegradation . Hence, Sodium [1,1'-biphenyl]-4-sulphonate can be considered as not readily biodegradable .

 

The above experimental data was further supported by experimental result summarized in J-CHECK Japan Chemicals Collaborative Knowledge database, 2017 for structurally similar read across substance Sodium 3-nitrobenzenesulphonate (CAS:127-68-4).

The test material Sodium 3-nitrobenzenesulfonate of initial concentration (100 mg/l) when subjected to activated sludge (30mg/l) for two weeks to evaluate biodegradation potential , the biodegradation percentage was observed to be 4.6, Hence, On the basis of above result Sodium 3 nitrobenzenesulfonate is considered to be not readily biodegradable.

On the basis of above results for target chemical4-chloro-3-nitrobenzenesulphonate(from OECD QSAR toolbox version 3.4 and EPI suite, 2017) and for its read across substance (from authoritative database J-CHECK & Chemosphere , Vol 28 , pp 2203-2236 1994), it can be concluded that the test substance4-chloro-3-nitrobenzenesulphonatecan be expected to be not readily biodegradable in nature.