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Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1974
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Principles of method if other than guideline:
BASF internal testing method
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2'-(2,5-dichloro-1,4-phenylene)bis(1H-anthra[1,2-d]imidazole-6,11-dione)
EC Number:
255-078-0
EC Name:
2,2'-(2,5-dichloro-1,4-phenylene)bis(1H-anthra[1,2-d]imidazole-6,11-dione)
Cas Number:
40783-05-9
Molecular formula:
C36H16Cl2N4O4
IUPAC Name:
2-(2,5-dichloro-4-{6,11-dioxo-1H,6H,11H-anthra[1,2-d]imidazol-2-yl}phenyl)-1H,6H,11H-anthra[1,2-d]imidazole-6,11-dione
Test material form:
solid

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
no data

Test system

Vehicle:
unchanged (no vehicle)
Controls:
other: Talcum
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 50 mg
Duration of treatment / exposure:
1 hour
Observation period (in vivo):
8 days
Number of animals or in vitro replicates:
no data
Details on study design:
Animals were observed after 1, 24 hours and 8 days.

SCORING SYSTEM:
Erythema and Edema
Ø - no effect
(+) - questionable
+ - mild
++ - moderate
+++ - marked

R - erythema
Ö - edema
Sch - desquamation
N - necrosis
Tr - opacity
Na - scar

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 8 d
Score:
0
Max. score:
4
Remarks on result:
no indication of irritation
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 8 d
Score:
0
Max. score:
2
Remarks on result:
no indication of irritation
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 8 d
Score:
0
Max. score:
3
Remarks on result:
no indication of irritation
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: 8 d
Score:
0
Max. score:
4
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
Within the first 24 h, slight redness, edema and opacity occurred. All symptoms disappeared within 8 d. No signs of corrosion observed.

The positive control (Talcum) caused slight irritation within 24 h corresponding to a normal reaction.
Other effects:
Yellow staining and smudgy secretions observed within 24 h.

Any other information on results incl. tables

Table 1: Results on Eye Irritation

Findings after
1 hour 24 hours 8 days
Test item R+/Ö+/yellow staining/secretion R+/Ö+/Tr+/smudgy secretion Ø
Talcum R+ R+ Ø

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The substance caused slight redness, edema and opacity within the first 24 h. However, no effect was significantly high and all symptoms disappeared within 8 d.