Registration Dossier
Registration Dossier
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EC number: 814-994-6 | CAS number: 123403-95-2
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
With high probability acutely not harmful to fish.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 531 mg/L
Additional information
Experimental data on the acute toxicity of EE-MOX (CAS 123403 -95 -2) to fish are not available. Therefore, the 96h LC50 was calculated to be 531 mg/L using the estimation model ECOSAR v1.11 implemented in EPISuite v4.11. (neutral organic; BASF SE, 2018). The substance is within the model's applicability domain. ECOSAR classifies the substance as a carbamate ester. Due to the poor database available for this chemical class, the substance was estimated with ECOSAR as a neutral organic.
Supporting experimental read-across data are available for the structurally analogous substance 5 -methyl-2-vinyloxazolidin-2-on (CAS 3395-98-0). In a 96 hour acute toxicity study, zebrafish (Danio rerio) were exposed the substance at nominal concentrations of 0 (control) and 120 mg/L under static conditions in accordance with the OECD 203 test guideline. The water pH, temperature and dissolved oxygen were within acceptable guideline specifications. The 96 hour LC50 was >120 mg/L based on nominal concentrations.
Based on all available data, the substance is considered to be with probability acutely not harmful to fish.
QSAR-disclaimer
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met. Furthermore according to Article 25 of the same Regulation testing on vertebrate animals shall be undertaken only as a last resort.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment of CAS 123403 -95 -2 (Q)SAR results were used for Acute Toxicity to Fish.The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.
Therefore, and for reasons of animal welfare, further experimental studies on Acute Toxicity to Fish are not provided.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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