Reaction mass of butane-1,3-diyl diacrylate and 1,3 butanediol diacrylate adduct with 1,3 butanediol monoacrylate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

Range-Finding Toxicity Data: List VIII.

Author:

Carpenter CP et al.

Year:

1974

Bibliographic source:

Toxicol. Appl. Pharmacol. 28: 313-319

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Range-finding toxicity test according to the method described by Smyth HF Jr. et al. (1962).
Smyth HF Jr. et al. (1962). Range-finding toxicity data: List VI. Amer. Ind. Hyg. Ass. J. 23: 95-107

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Butane-1,3-diyl diacrylate

EC Number:

243-105-9

EC Name:

Butane-1,3-diyl diacrylate

Cas Number:

19485-03-1

Molecular formula:

C10H14O4

IUPAC Name:

butane-1,3-diyl bisacrylate

Details on test material:

no data

Test animals

Species:

rat

Strain:

Wistar

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Age at study initiation: 4-5 weeks
- Weight at study initiation: 90-120 g
- Fasting period before study: no

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

not specified

Doses:

The dosages were arranged in a logarithmic series differing by a factor of two.

No. of animals per sex per dose:

6 males

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Test conditions and method according to Smyth et al. (1962):
Single oral dose toxicity was estimated by the gastric intubation of groups of five non-fasted, Carworth-Wistar male rats, or in rare instances of female rats, four to five weeks of age and 90 to 120 grams. The dosages were arranged in a logarithmic series differing by a factor of two. Whenever possible, the chemical was administered undiluted. When a lesser concentration was necessary, solution in water or corn oil or suspension in semi-solid agar were the preferred expedients. Occasionally, a 1 % solution of Tergitol penetrant 7 (essentially an aqueous solution of 25 % sodium 3,9-diethyl-6-tridecanol sulfate) has been used as a dispersing agent. Based upon mortalities during a 14-day observation period, the most probable LD50 value and its fiducial range were estimated by the method of Thompson (1947).

Statistics:

The most probable LD50 value and its fiducial range were estimated by the method of Thompson (1947).

Thompson WR (1947). Use of Moving Averages and Interpolation to Estimate  Median Effective Dose. Bacteriol. Rev. 11: 115

Results and discussion

Effect levels

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

3.45 mL/kg bw

Based on:

test mat.

95% CL:

> 2.57 - < 4.87

Remarks on result:

other: with a density of 1.037, the LD50 is 3577 mg/kg bw

Mortality:

yes, no details

Clinical signs:

no data

Body weight:

no data

Gross pathology:

no data

Other findings:

no data

Applicant's summary and conclusion

Interpretation of results:

Category 5 based on GHS criteria

Conclusions:

Based on the results, the oral LD50 of 1,3-butylene glycol diacrylate is 3577 mg/kg (corresponding to 3.45 ml/kg bw) in rats.