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Boiling point

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boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 19 to 25 Octobre 2016
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
The study was conducted according to an internationally recognised method, and under GLP. No deviation was reported. Test substance is adequately specified. Therefore full validation applies.
according to guideline
OECD Guideline 103 (Boiling Point)
Version / remarks:
according to guideline
EU Method A.2 (Boiling Temperature)
Version / remarks:
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes (incl. QA statement)
Type of method:
dynamic method
Cottrell pump is used in the main test (pre-test with Siwoloboff method is performed)
Key result
Decomp. temp.:
ca. 220 °C
Remarks on result:
not determinable

First, a pre-test following Siwoloboff method was performed, but the colour of the test item changed into a darker colour (potentially due to decomposition of the substance). It was not possible to see a boiling chain. Therefore, the Siwoloboff method is not considered as suitable for the main test.

Secondly, the main determination was performed following the dynamic method.

Observations and measured values are presented in the following tables:

Table 4.3.1 Results:

 Decomposition  Temperature Cottrell pump  Temperature test item
 First determination  194.5°C  243.0°C (516.2K)
 Second determination  202.0°C  243.0°C (516.2K)
 Mean    243.0°C (516.2K)

Table 4.3.2 Observations:

 Observations  Temperature test item
 small bubbles  90°C
 more bubbles  140°C
 colour slightly greenish  220°C
 colour greenish  232°C

After cooling down the test item was like wax but stay greenish.

Boiling, indicated by pumping of the Cottrell pump, was observed at 194.5 °C (first determination) and 202 °C (second determination), while the temperature measured in the sample was 243°C.

During the boiling of a pure substance, the temperature in the sample should be the same as the temperature of the Cottrell pump. Otherwise the temperature difference between the thermometers should be a sign of decomposition of the pure substance.

For this complex substance, the thermometer in the Cottrell pump showed a lower temperature than the temperature in the sample, which may be the sign of decomposition. In addition, the colour change of the test item after cooling down indicated clearly decomposition of the test item during the experiment.

Considering the complex nature of the substance, the temperature of initial decomposition of the test item cannot be clearly determined using these methods. However signs of decomposition of the substance (such as change of colour and difference between temperatures of the test item and in the Cottrell pump) were observed from 220°C.

As the test item showed decomposition, the calculation following the equation of Sydney – Young was not necessary.

No observations were made which might cause doubts on the validity of the study outcome. Therefore, the result of the study is considered valid.

No boiling point was recorded due to decomposition of the substance.
Executive summary:

A study was conducted to determine the boiling point of the test substance under GLP according to OECD 103 / EU A2 guideline.

No boiling point was determined because of decomposition of the test item observed (colour change and temperature difference between test item and the Cottrell pump)

The temperature of initial decomposition of the substance is not clear. Condering the observations reported using Siwoloboff and Cottrell methods, the initial decomposition is considered to be observed from approximately 220°C (colour change).

According to Regulation (EC) No 1907/2006 (REACH) annex VII, column 2 of section 7.3, the determination of the boiling point does not need to be conducted for substances which decompose before boiling (e.g. auto-oxydation, rearrangement, degradation, decomposition, etc...)Therefore no additional test was conducted.

Description of key information

No boiling point was recorded due to the decomposition of the test item before boiling.

Key value for chemical safety assessment

Additional information

A reliable GLP experimental study, conducted according to a recognized OECD/EC guidelines is available.

It is considered as a key study.