Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-898-4 | CAS number: 111-71-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Short-term toxicity to aquatic invertebrates:
- EC50 (48h) & LC50 (48h) = 4.13 mg/L for Daphnia magna (OECD TG 202)
- NOEC = 1.86 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 4.13 mg/L
Additional information
Two reliable studies are available for this endpoint:
(1) WARD T.J., WYSKIEL D.C. and BOERI R.L. (2003)
(2) STEPHENSON R.R. (1982)
The first study was conducted in accordance with OECD test guidelines 202 and in compliance with OECD (1997) Good Laboratory Practice standards. OECD validity criteria were fulfilled. The concentration of the substance being tested has been recorded and maintained throughout the test; the mean measured concentrations were used to calculate median effective concentration (EC50s).
The second study didn’t satisfy all these conditions: GLP compliance is not mentioned in the study report and no analytical monitoring has been performed. Therefore, it was not possible to check that the concentration of the substance has been satisfactorily maintained during the test.
Based on these observations, the first study is considered as the key study. The second one less reliable can't be considered as supporting study because the EC50 value determined in this study led to a less severe classification (i.e. EC50 = 54 mg/L).
So, only the key study summary is developed below:
The study was performed in 2003 at T.R. Wilbury Laboratories, Inc. to assess the acute toxicity of heptanal to the daphnid, Daphnia magna.
The test was performed for 48 hours under flow-through conditions with five concentrations of test substance at a temperature of 20 ± 1°C. Nominal concentrations of heptanal were: 0 mg/L (control and solvent control), 2.6, 4.4, 7.2, 12, and 20 mg/L. Mean measured concentrations of heptanal were: ND (none detected at or above the limit of quantification; control and solvent control), 1.86, 3.12, 5.10, 9.78, and 13.8 mg/L. These mean measured concentrations, which ranged from 69 to 82% of nominal concentrations, were used in this study to calculate median effective concentration (EC50). Insoluble material was not observed at any tested concentration during the definitive test.
Twenty daphnids (less than 24 hours old) were equally distributed among two replicates of each treatment. During the toxicity test, the numbers of surviving organisms, the occurrence of immobility and sublethal effects, and the presence of insoluble material were determined visually and recorded after 0, 24, and 48 hours.
Exposure of daphnids to heptanal resulted in a 48 hour median effective concentration (EC50) of 4.13 mg/L (95% confidence interval = 3.41 to 4.96 mg/L). The 48 hour no observed effect concentration (NOEC) was 1.86 mg/L. Based on the results of this study, Heptanal is considered as toxic to aquatic organisms tested in accordance with the Directive 67/548/EC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
