Registration Dossier

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
data is from safety assessment report

Data source

Reference
Reference Type:
secondary source
Title:
SIDS Dossier for CAS no: 6358-85-6
Author:
OECD SIDS
Year:
2003
Bibliographic source:
OECD HPV Chemical Programme, SIDS Dossier, approved at SIAM 16 (27/05/2003)

Materials and methods

Principles of method if other than guideline:
A patch test of C. I. Pigment Yellow 12 (CAS no: 6358-85-6) was conducted on rabbits to determine the degree of skin irritation under occlusive condition.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Details on test material:
- Name of test material (as cited in study report): C. I. Pigment Yellow 12
- Molecular formula: C32H26Cl2N6O4
- Molecular weight: 629.5014 g/mol
- Substance type: organic
- Physical state: solid
Specific details on test material used for the study:
- Name of test material (as cited in study report): C. I. Pigment Yellow 12
- Molecular formula: C32H26Cl2N6O4
- Molecular weight: 629.5014 g/mol
- Substance type: organic
- Physical state: solid

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals and environmental conditions:
No data available

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
not specified
Amount / concentration applied:
No data available
Duration of treatment / exposure:
24 hours
Observation period:
24 hours
Number of animals:
No data available
Details on study design:
No data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24 h
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No adverse effects were observed.

Applicant's summary and conclusion

Interpretation of results:
other: Not irritating
Conclusions:
The chemical C. I. Pigment Yellow 12 (CAS no: 6358-85-6) was considered as not irritating to the skin of rabbits.
Executive summary:

A patch test of C. I. Pigment Yellow 12 (CAS no: 6358-85-6) was conducted on rabbits to determine the degree of skin irritation.

 

When chemical C. I. Pigment Yellow 12 was applied on each rabbit for 24 hours under occlusive condition, no skin reactions were observed. Hence the chemical C. I. Pigment Yellow 12 (CAS no: 6358-85-6) was considered as not irritating to the skin of rabbits.