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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from Authoritative database.

Data source

Reference
Reference Type:
other: Authoritative database.
Title:
Acute oral toxicity study of Pigment Yellow 13 (CAS no: 5102-83-0) in Rat.
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
ChemIDplus, A TOXNET DATABASE, Lite Browse Advanced, 2017.

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: As mentioned below
Principles of method if other than guideline:
The acute oral toxicity test of 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(2,4-dimethylphenyl)-3-oxobutyramide] (CAS no: 5102-83-0) in rat.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Name: 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(2,4-dimethylphenyl)-3-oxobutyramide]
InChI:1S/C36H34Cl2N6O4/c1-19-7-11-29(21(3)15-19)39-35(47)33(23(5)45)43-41-31-13-9-25(17-27(31)37)26-10-14-32(28(38)18-26)42-44-34(24(6)46)36(48)40-30-12-8-20(2)16-22(30)4/h7-18,33-34H,1-6H3,(H,39,47)(H,40,48)/b43-41+,44-42+
Smiles: C([C@@H](\N=N\c1c(cc(cc1)c1cc(Cl)c(\N=N\ [C@@H](C(Nc2c(cc(cc2)C)C)=O)C(=O)C)cc1)Cl) C(=O)C)(Nc1c(cc(cc1)C)C)=O
- Name of test material (as cited in study report):Pigment Yellow 13
- Molecular formula (if other than submission substance):C36H34Cl2N6O4
- Molecular weight (if other than submission substance):685.609 g/mol
- Substance type:Organic
Specific details on test material used for the study:
Name: 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(2,4-dimethylphenyl)-3-oxobutyramide]
InChI:1S/C36H34Cl2N6O4/c1-19-7-11-29(21(3)15-19)39-35(47)33(23(5)45)43-41-31-13-9-25(17-27(31)37)26-10-14-32(28(38)18-26)42-44-34(24(6)46)36(48)40-30-12-8-20(2)16-22(30)4/h7-18,33-34H,1-6H3,(H,39,47)(H,40,48)/b43-41+,44-42+
Smiles: C([C@@H](\N=N\c1c(cc(cc1)c1cc(Cl)c(\N=N\ [C@@H](C(Nc2c(cc(cc2)C)C)=O)C(=O)C)cc1)Cl) C(=O)C)(Nc1c(cc(cc1)C)C)=O
- Name of test material (as cited in study report):Pigment Yellow 13
- Molecular formula (if other than submission substance):C36H34Cl2N6O4
- Molecular weight (if other than submission substance):685.609 g/mol
- Substance type:Organic

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
not specified
Doses:
5000 mg/kg
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality was observed
Mortality:
No mortality was observed at 5000 mg/kg bw.
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
The acute oral LD50 value was considered to be >5000 mg/kg bw, when rats were treated with 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(2,4-dimethylphenyl)-3-oxobutyramide] (CAS no: 5102-83-0) via oral route.
Executive summary:

Acute oral toxicity study of 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(2,4-dimethylphenyl)-3-oxobutyramide] (CAS no: 5102-83-0) was conducted in rats at the concentration of 5000 mg/kg bw. No mortality was observed in treated rats at 5000 mg/kg bw. Therefore, LD50 was considered to be >5000 mg/kg bw, when rats were treated with 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(2,4-dimethylphenyl)-3-oxobutyramide] via oral route.