Registration Dossier
Registration Dossier
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EC number: 268-697-6 | CAS number: 68133-69-7
Endpoint summary
Administrative data
Description of key information
Acute toxicity in rats
LD50 > 5000 mg/kg
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
A sample with low purity (ca. 30 % dye) was tested for acute oral toxicity to rats. Apart from the dye, remaining components were mainly sodium lignosulphonate as dispersant (69 %) and dedustant (1 %).
12.5 ml/kg of suspension with test substance was administered to male and female rats (5 sex/dose) by gavage. Doses of test substance were 0 mg/kg (control) and 5000 mg/kg. Only one female rat died after dosing. Therefore, LD50 > 5000 mg/kg was found.
Signs of treatment reaction were noted, e.g. pilo-erection, hunched posture, waddling. Recovery of survivors was complete within 3 days, as shown by normal bodyweight gains and normal autopsy findings.
Lethargy, pallor of extremities and ptosis was noted in one female prior to death. Such female showed congestion of lungs, pallor of liver, kidneys and spleen at autopsy.
Justification for classification or non-classification
According to the CLP Regulation (EC 1272/2008), substances can be allocated to one of four toxicity categories based on acute toxicity by oral, dermal or inhalation route according to numeric criteria. Acute toxicity values are expressed as LD50 (oral, dermal) or LC50 (inhalation) values as well as acute toxicity estimates (ATE).
In available studies in rats, oral LD50 values above 2000 mg/kg bw were found. Accordingly, target substance was not classified for acute oral toxicity in the CLP Regulation (EC 1272/2008).
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