2-phenoxyethyl methacrylate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1981

Report date:

1981

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

yes

Remarks:

two doses were used

Principles of method if other than guideline:

14 days acut toxicity study with one oral exposure, two doses 2150 and 5000 mg/kg.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-phenoxyethyl acrylate

EC Number:

256-360-6

EC Name:

2-phenoxyethyl acrylate

Cas Number:

48145-04-6

Molecular formula:

C11H12O3

IUPAC Name:

2-phenoxyethyl prop-2-enoate

Test material form:

other: liquid dissolved in olive oil

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

5 males and 5 females per concentration, approximately 12 weeks at start. At least one week acclimatization.
Food; SSNIFF R; FA.SSNIFF, Versuchstierdiaeten; 4470 Soest

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

olive oil

No. of animals per sex per dose:

5

Control animals:

no

Results and discussion

Effect levels

Key result

Sex:

female

Dose descriptor:

LD0

Effect level:

5 000 mg/kg bw

Based on:

test mat.

Mortality:

No mortality was observed

Clinical signs:

other: At highest dose, 5000 mg/kg bw; Dyspnea, staggering and overall bad condition were observed after one hour and untill 2 days. Shaggy fur was observed between 1 and 13 days. Apathy, anormalous behavior, signs of pain, spastic walking, redness of skin, dry

Applicant's summary and conclusion

Interpretation of results:

sligthly toxic

Remarks:

Migrated information

Conclusions:

No mortality were observed in any of the two doses tested. The acute LD50 value is therefore above 5000 mg/kg

Executive summary:

The acute toxicity of phenoxyethyl acrylate was tested in a single dose acute toxicity test, comparable to OECD Guideline 401. Two doses were tested 2150 and 5000 mg/kg. The substance was giving orally dissolved in olive oil, total volume was 5 and 10 ml/kg bw, which is acceptable according to the OECD guideline. Several clinical signs were observed, such as dyspnoea, shaggering, shaggy fur, redness of skin and hemi paralysis. The symptoms gradually ceased within hours to two days, except shaggy fur in the highest dose. No mortality was observed at any of the doses, therefore the acute LD50 value is above 5000 mg/kg.