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EC number: 255-424-0 | CAS number: 41519-23-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
WoE appraoch based on the two Klimish 4 tests below :
- Acute Oral Toxicity Of Selected Flavor Chemicals, Drug And Chemical Toxicology, 3(3), 249-258 dated on 1980 _ LD50 (Oral) = 250000 ml/Kg bw
- Acute Oral toxicity in rats on Cis-3-Hexenyl Isobutyrate abstract_ dated on 1976_LD50 (Oral) > 5000 mg/Kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1976
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
- Remarks:
- 1 page summary
- Qualifier:
- according to guideline
- Guideline:
- other: no guideline specified on the 1 page study summary
- GLP compliance:
- no
- Limit test:
- yes
- Specific details on test material used for the study:
- No 76-1277, Cis-3-hexenyl isobutyrate
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No death occurred
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 of HEXENYL-3-CIS ISOBUTYRATE in rat has been determined to be above 5'000 mg/Kg bw. Hence the GHS criteria are not met for classification.
- Executive summary:
The LD50 of HEXENYL-3-CIS ISOBUTYRATE in rat has been determined to be above 5'000 mg/Kg bw. Hence the GHS criteria are not met for classification.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1980
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Qualifier:
- according to guideline
- Guideline:
- other: see the protocole description in the field "Principle of method of other than guideline"
- Principles of method if other than guideline:
- Groups of ten animals, five males and five females, weighing 15 to 35 g for mice (Swiss Webster, Southern Animal Farms, Pratville,_ Alabama or BLU :Ha(1CR), Blue Spruce Farms, Altamont, New York) and 40 to 60 g for rats, (FDRL Strain, Waverly, New York) were fasted overnight prior to treatment . The test substance was administered by oral gavage as a solution or suspension in corn oil . The concentration of the test substance in corn oil was adjusted so that each group of,animals in a particular study received the same volume of solution with respect to body weight . Animals had free access to water at all times and to feed (Purina Laboratory Chow) following dosing .
Animals were closely observed for mortality and pharmacologic effects on the day of dosing and daily thereafter for a total of 14 observation days . Rats were weighed prior to dosing . LD50s were calculated by appropriate statistical methods, as determined by the data (see tabular citations) . - GLP compliance:
- no
- Limit test:
- yes
- Specific details on test material used for the study:
- TEST MATERIAL
Name as stated in the report : 3-hexenyl isobutyrate - Species:
- other: rats and mice
- Strain:
- other: Swiss Webster, Southern Animal Farms, Pratville,_ Alabama or BLU :Ha(1CR) and FDRL Strain, Waverly, New York
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- weight: 15 to 35 g for mice 40 to 60 g for rats
Animals had free access towater at all times and to feed (Purina Laboratory Chow) following dosing . - Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 25,000 mg/kg
- No. of animals per sex per dose:
- 1 dose per animal
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 25 000 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 of HEXENYL-3-CIS ISOBUTYRATE in rat is likely to be in excess of 25 0000 ml/Kg bw. Hence the GHS criteria are not met for classification.
- Executive summary:
The LD50 of HEXENYL-3-CIS ISOBUTYRATE in rat is likely to be in excess of 25 0000 ml/Kg bw. Hence the GHS criteria are not met for classification.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Additional information
Justification for classification or non-classification
The LD50 values of HEXENYL-3-CIS ISOBUTYRATE have been determined to be above 5'000 mg/Kg bw in the 2 tests mentionned above. Hence the GHS criteria are not met for any Acute Oral classification.
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