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Registration Dossier
Diss Factsheets
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EC number: 946-272-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Hazard for air
Hazard for terrestrial organisms
Hazard for predators
Additional information
Conclusion on classification
For the endpoint aquatic toxicity two GLP-compliant key studies with the registered substance were conducted. The acute toxicity to D. magna was studied with an Acute Immobilisation test according to the OECD Guideline 202. The EC50 (48 h) value was 1.6 mg/L. The toxicity to aquatic algae was investigated with a Growth Inhibition study on P. subcapitata according to the OECD Guideline 201. The EC50 (72 h) value (referring the growth rate) was 0.94 mg/L. The key values are in a range of copper toxicities identified in a number of studies. The key value of 0.94 mg/L obtained in the Growth Inhibition key study according to the OECD Guideline 201 (Kamle, 2017) is just below the limit of 1 ml/L for classification as hazardous to the aquatic environment, acute category 1. Due to the fact that there is evidence that the toxicity of copper strongly depends on environmental factors not accounted for in laboratory studies, laboratory results lead to an overestimation of copper toxicity when compared to the situation in field. Factors significantly reducing copper toxicity are dissolved organic carbon content (Kramer et al. 2004, De Schampelaere et al. 2004, and 2002), low pH-value, Calcium (De Schamphelaere et al. 2002), Sodium (De Schamphelaere et al. 2004) and increasing hardness of water (Lloyd 1961). Therefore, the substance Copper glucoheptonate is not intended to be classified as hazardous to the environment, taking into account the provisions laid down in Council Directive 67/548/EEC and CLP Regulation (EC) No 1272/2008.
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