Registration Dossier
Registration Dossier
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EC number: 212-042-9 | CAS number: 754-05-2
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
Episuite is a well known QSAR software package that is widely used and accepted by both industry and regulatory authorities.
Trimethylvinylsilane is considered to be inside the applicability domain of the EpiSuite ECOSAR model since the following criteria are fulfilled (as described in the model's manual):
- The molecular weight of trimethylvinylsilane is within the molecular weight range of the training set
- Trimethylvinylsilane is within the log Kow range of the training set
Data source
Reference
- Reference Type:
- other: QSAR
- Title:
- ECOSAR v. 1.11
- Author:
- EPA's Office of Chemical Safety and Pollution Prevention
- Year:
- 2 012
- Bibliographic source:
- https://www.epa.gov/tsca-screening-tools/ecological-structure-activity-relationships-ecosar-predictive-model
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- QSAR calculation based on the log Kow of the substance.
- GLP compliance:
- no
Test material
- Reference substance name:
- Trimethylvinylsilane
- EC Number:
- 212-042-9
- EC Name:
- Trimethylvinylsilane
- Cas Number:
- 754-05-2
- Molecular formula:
- C5H12Si
- IUPAC Name:
- trimethylvinylsilane
1
Results and discussion
Effect concentrations
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 5.8 mg/L
Applicant's summary and conclusion
- Conclusions:
- 48h-EC50 in daphnids: 5.80 mg/L, as determined by means of EpiSuite's ECOSAR model.
- Executive summary:
The 48h-EC50 in daphnids was retrieved from EpiSuite's ECOSAR model and was found to be 5.80 mg/L.
Trimethylvinylsilane is considered to be inside the applicability domain of the EpiSuite WSKOW model since the following criteria are fulfilled:
- The molecular weight of trimethylvinylsilane is within the molecular weight range of the training set.
- Trimethylvinylsilane is within the log Kow range of the training set.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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