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Hydrolysis:

The half life of hydrolysis of test chemical 2-chlorobenzene-1,4-diammonium sulphate (CAS no. 6219 -71 -2) was estimated by uisng OECD QSAR tool box v3.3 and

by considering five closest read across chemical with log Kow as primary descriptor. The half life of hydrolysis of test chemical  2-chlorobenzene-1,4-diammonium sulphate was estimated to be 127.91 days. On the basis of this half life value it is concluded that this test chemical is shows negligible hydrolysis that means it not hydrolysable.

Additional information

Hydrolysis:

Predicted data study for target chemical 2-chlorobenzene-1,4-diammonium sulphate (CAS no. 6219 -71 -2) and experimental study for its structurally similar read across chemical are summarized below for hydrolysis enpoint.

In predicted data study the half life of hydrolysis of test chemical 2-chlorobenzene-1,4-diammonium sulphate (CAS no. 6219 -71 -2) was estimated by using OECD QSAR tool box v3.3 and

by considering five closest read across chemical with log Kow as primary descriptor. The half life of hydrolysis of test chemical  2-chlorobenzene-1,4-diammonium sulphate was estimated to be 127.91 days. On the basis of this half life value it is concluded that this test chemical is shows negligible hydrolysis that means it not hydrolysable.

Next the supporting experimental study was done from authoritative database (HSDB, 2017) i this study the hydrolysis rate constant of read across chemical 4-aminobenzenesulfonic acid obtained was 2.9X10+9 L/mol-sec L/mol/sec The half life of hydrolysis obtained at pH 7 was 276 days . Since half life of hydrolysis  is more than 10 days so it is concluded that read across chemical 4-aminobenzenesulfonic acid shows negligible hydrolysis that means it is not hydrolysable.

On the basis of both the studies mentioned above it can be concluded that this test chemical 2-chlorobenzene-1,4-diammonium sulphate (CAS no. 6219 -71 -2)

is not hydrolysable.