Registration Dossier
Registration Dossier
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EC number: 209-669-5 | CAS number: 590-01-2
Endpoint summary
Administrative data
Description of key information
In a non-GLP study conducted following methodology equivalent to OECD TG 404, the mean erythema and edema scores over New Zealand White 6 rabbits exposed to 0.5 ml of butyl propionate was 0, i.e. no signs of erythema and edema were noted in any of the exposed animals.
In a non-GLP study conducted following methodology equivalent to OECD TG 405, the mean corneal, iris, chemosis and conjunctival scores over 6 New Zealand White rabbits exposed to 0.1 ml of butyl propionate was 0, i.e. no signs of eye irritation were noted in any of the exposed animals.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation -
In a non-GLP study conducted following methodology equivalent to OECD TG 404, the mean erythema and edema scores over 6 New Zealand White rabbits exposed to 0.5 ml of pentyl propionate was 0, i.e. no signs of erythema and edema were noted in any of the exposed animals.
Eye irritation -
In a non-GLP study conduced following methodology equivalent to OECD TG 405, Instillation of 0.1 ml of sample into rabbit eyes resulted in no corneal injury (opacity) in any of 6 animals. Transient iritis was apparent in 2 eyes and minor to moderate conjunctival irritation developed in 6 rabbits within one hour. A substantial amount of discharge was noted in each eye. After 24 hours, only minor conjunctival redness remained in all rabbits. By 48 hours, 5 eyes had a normal appearance. All 6 eyes were healed after 72 hours
Respiratory irritation -
The key studies for repeated dose toxicity indicate that irritation of the upper respiratory tract at high concentrations occurs. However the data are not sufficient to lead to a conclusion for classification. In addition, no reports of upper respiratory tract or respiratory irritation have been reported from workers handling the material.
Justification for classification or non-classification
In the absence of any skin, eye or respiratory irritation and based on the Guidance to Regulation (EC) No. 1272/2008 on Classification, Labelling and Packaging of substances and mixtures, pentyl propionate will not be classified as a skin or an eye or a respiratory irritant.
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