Registration Dossier
Registration Dossier
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EC number: 209-669-5 | CAS number: 590-01-2
Endpoint summary
Administrative data
Description of key information
Acute oral - In a non-GLP study conducted with study methodology equivalent to OECD TG 401, the LD50 value of butyl propionate to male and female Sprague Dawley rats was > 14 ml/kg (Conversion from ml/kg to mg/kg resulted in - 14.1 ml/kg - 12345 mg/kg (based on density of 0.87)).
Acute dermal - In a non-GLP study conducted with study methodology equivalent to OECD TG 402, the acute dermal LD50 value of butyl propionate to male and female New Zealand rabbits was > 16 ml/kg (Conversion from ml/kg to mg/kg resulted in - 16 ml/kg - 14008 mg/kg (based on density of 0.87)).
Acute inhalation - In a non-GLP study conducted with study methodology equivalent to OECD TG 403, the acute inhalation LC50 value of butyl propionate to male and female Sprague Dawley rats exposed to saturated vapors over a period of 6 hours was 10070 mg/m3 or 10.07 mg/l (based on conversion).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- marvellous
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- marvellous
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- marvellous
Additional information
Acute oral -
Under the conditions of the study, the LD50 of UCAR n-butyl propionate to male Sprague Dawley rats was 14.1 ml/kg (95% CL - 12.1-16.4; 12344.55 mg/kg) and female Sprague Dawley
Acute dermal -
In a non-GLP study conducted with study methodology equivalent to OECD TG 402, the acute dermal LD50 value of butyl propionate to male and female New Zealand rabbits was > 16 ml/kg (Conversion from ml/kg to mg/kg resulted in - 16 ml/kg - 14008 mg/kg (based on density of 0.87)).
Acute inhalation -
In a non-GLP study conducted with study methodology equivalent to OECD TG 403, the acute inhalation LC50 value of butyl propionate to male and female Sprague Dawley rats exposed to saturated vapors over a period of 6 hours was >23.78 mg/l (23780 mg/m3).
Justification for classification or non-classification
Based on the acute oral, dermal and inhalation LD/LC50 values noted and based on the Guidance to Regulation (EC) No. 1272/2008 on Classification, Labelling and Packaging of substances and mixtures, butyl propionate will not be classified for acute toxicity via oral, dermal and inhalation routes of exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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