Registration Dossier
Registration Dossier
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EC number: 265-198-5 | CAS number: 64742-94-5 A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C9 through C16 and boiling in the range of approximately 165°C to 290°C (330°F to 554°F).
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
- Objective of study:
- absorption
- Principles of method if other than guideline:
- Test guideline is unknown
- GLP compliance:
- yes
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- IUCLID4 Test substance: other TS: Blend of straight run hydrotreated kerosine (30%) and hydrocracked kerosine (70%)
Constituent 1
Test animals
- Species:
- mouse
Administration / exposure
- Route of administration:
- dermal
- Vehicle:
- other: mineral oil
- Duration and frequency of treatment / exposure:
- 96 hour(s)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Males: 15 µl undiluted and 60 µl diluted to 25% with mineral oil
- No. of animals per sex per dose / concentration:
- Males: 5
Results and discussion
Toxicokinetic / pharmacokinetic studies
Toxicokinetic parametersopen allclose all
- Toxicokinetic parameters:
- half-life 1st:
- Toxicokinetic parameters:
- half-life 2nd:
- Toxicokinetic parameters:
- half-life 3rd:
Any other information on results incl. tables
In
the study with dermally applied undiluted test material approximately 5%
of the labelled tetradecane and 15% of the labelled naphthalene was absorbed
over 96 hours.
In the study with the 25% concentration of test material, approximately 7%
of the labelled tetradecane and 16% of the labelled naphthalene was absorbed
over 96 hours.
In the passive inhalation study approximately 2.8% (undiluted test material)
and 1.8% (25% concentration) of the labelled naphthalene was available. In
contrast, approximately 0.2% of labelled tetradecane in undiluted
and diluted test material was absorbed.
These studies demonstrate that dilution of the test material in mineral oil
did not influence absorption of the radiolabelled
"spikes" present.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
