2-methoxybenzyl alcohol

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from peer reviewed journal

Data source

Reference

Reference Type:

publication

Title:

A toxicological and dermatological assessment of aryl alkyl alcohols when used as fragrance ingredients.

Author:

D. Belsito, D. Bickers, M. Bruze, P. Calow, M.L. Dagli, A.D. Fryer, H. Greim, Y. Miyachi, J.H. Saurat , I.G. Sipes

Year:

2012

Bibliographic source:

Food and Chemical Toxicology, Vol. 50, Pg. no. S52-S99, 2012.

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

A skin irritation study was conducted to assess the skin irritation potential of chemical 2-Methoxybenzyl alcohol (CAS no: 612-16-8) on human volunteers as a part of induction of human repeated insult patch test.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2-methoxybenzyl alcohol

EC Number:

210-296-5

EC Name:

2-methoxybenzyl alcohol

Cas Number:

612-16-8

Molecular formula:

C8H10O2

IUPAC Name:

(2-methoxyphenyl)methanol

Test material form:

liquid

Details on test material:

- Name of test material : (2-methoxyphenyl)methanol
- Common name : 2-Methoxybenzyl alcohol
- Molecular formula : C8H10O2
- Molecular weight : 138.165 g/mol
- Smiles notation : O(c1c(cccc1)CO)C
- InChl : 1S/C8H10O2/c1-10-8-5-3-2-4-7(8)6-9/h2-5,9H,6H2,1H3
- Substance type: Organic
- Physical state: Liquid

Specific details on test material used for the study:

- Name of test material (as cited in study report): 2-Methoxybenzyl alcohol
- Molecular formula: C8H10O2
- Molecular weight: 138.165 g/mol
- Substance type: Organic
- Physical state: liquid
-Smiles: O(c1c(cccc1)CO)C
-InChI: 1S/C8H10O2/c1-10-8-5-3-2-4-7(8)6-9/h2-5,9H,6H2,1H3

Test animals

Species:

other: Human

Strain:

other: Not applicable

Details on test animals or test system and environmental conditions:

No data available

Test system

Type of coverage:

occlusive

Preparation of test site:

not specified

Vehicle:

other: Ethyl alcohol (EtOH)

Controls:

not specified

Amount / concentration applied:

1.2%

Duration of treatment / exposure:

No data available

Observation period:

No data available

Number of animals:

39

Details on study design:

No data available

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Reversibility:

not specified

Remarks on result:

other: Slight erythema was observed at one reading only in 4 out of 39 subjects. No irritation was observed in remaining subjects.

Irritant / corrosive response data:

Slight erythema was observed at one reading only in 4 out of 39 subjects. No irritation was observed in remaining subjects.

Applicant's summary and conclusion

Interpretation of results:

other: Not irritating

Conclusions:

The test material 2-Methoxybenzyl alcohol (CAS no: 612-16-8) was considered to be not irritating to the skin of human volunteers.

Executive summary:

A skin irritation study was conducted to assess the skin irritation potential of chemical 2-Methoxybenzyl alcohol (CAS no: 612-16-8) on human volunteers as a part of induction of human repeated insult patch test.

 

The chemical was applied to the skin of each subjects at a dose of 1.2% in ethyl alcohol and later observed for skin reaction.

 

Slight erythema was observed at one reading only in 4 out of 39 subjects. No irritation was observed in remaining subjects.

 

Since the majority of treated volunteers did not show any signs of skin reactions,the chemical2-Methoxybenzyl alcohol (CAS no: 612-16-8) was considered to be not irritating to the skin of human volunteers.