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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer reviewed journal

Data source

Reference
Reference Type:
publication
Title:
A toxicological and dermatological assessment of aryl alkyl alcohols when used as fragrance ingredients.
Author:
D. Belsito, D. Bickers, M. Bruze, P. Calow, M.L. Dagli, A.D. Fryer, H. Greim, Y. Miyachi, J.H. Saurat , I.G. Sipes
Year:
2012
Bibliographic source:
Food and Chemical Toxicology, Vol. 50, Pg. no. S52-S99, 2012.

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
A skin irritation study was conducted to assess the skin irritation potential of chemical 2-Methoxybenzyl alcohol (CAS no: 612-16-8) on human volunteers as a part of induction of human repeated insult patch test.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
- Name of test material : (2-methoxyphenyl)methanol
- Common name : 2-Methoxybenzyl alcohol
- Molecular formula : C8H10O2
- Molecular weight : 138.165 g/mol
- Smiles notation : O(c1c(cccc1)CO)C
- InChl : 1S/C8H10O2/c1-10-8-5-3-2-4-7(8)6-9/h2-5,9H,6H2,1H3
- Substance type: Organic
- Physical state: Liquid
Specific details on test material used for the study:
- Name of test material (as cited in study report): 2-Methoxybenzyl alcohol
- Molecular formula: C8H10O2
- Molecular weight: 138.165 g/mol
- Substance type: Organic
- Physical state: liquid
-Smiles: O(c1c(cccc1)CO)C
-InChI: 1S/C8H10O2/c1-10-8-5-3-2-4-7(8)6-9/h2-5,9H,6H2,1H3

Test animals

Species:
other: Human
Strain:
other: Not applicable
Details on test animals and environmental conditions:
No data available

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
other: Ethyl alcohol (EtOH)
Controls:
not specified
Amount / concentration applied:
1.2%
Duration of treatment / exposure:
No data available
Observation period:
No data available
Number of animals:
39
Details on study design:
No data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Reversibility:
not specified
Remarks on result:
other: Slight erythema was observed at one reading only in 4 out of 39 subjects. No irritation was observed in remaining subjects.
Irritant / corrosive response data:
Slight erythema was observed at one reading only in 4 out of 39 subjects. No irritation was observed in remaining subjects.

Applicant's summary and conclusion

Interpretation of results:
other: Not irritating
Conclusions:
The test material 2-Methoxybenzyl alcohol (CAS no: 612-16-8) was considered to be not irritating to the skin of human volunteers.

Executive summary:

A skin irritation study was conducted to assess the skin irritation potential of chemical 2-Methoxybenzyl alcohol (CAS no: 612-16-8) on human volunteers as a part of induction of human repeated insult patch test.

 

The chemical was applied to the skin of each subjects at a dose of 1.2% in ethyl alcohol and later observed for skin reaction.

 

Slight erythema was observed at one reading only in 4 out of 39 subjects. No irritation was observed in remaining subjects.

 

Since the majority of treated volunteers did not show any signs of skin reactions,the chemical2-Methoxybenzyl alcohol (CAS no: 612-16-8) was considered to be not irritating to the skin of human volunteers.