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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from Publication.

Data source

Reference
Reference Type:
publication
Title:
Fragrance raw materials monographs: Benzyl alcohol
Author:
D. L. J. Opdyke
Year:
1973
Bibliographic source:
Food and Cosmetics Toxicology, Volume 11, Issue 6, December 1973, Pages 1011-1013.

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as metioned below
Principles of method if other than guideline:
Acute oral toxicity study of Benzyl alcohol (100-51-6) in rat..
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
Name: Benzyl alcohol
InChI: 1S/C7H8O/c8-6-7-4-2-1-3-5-7/h1-5,8H,6H2
Smiles: OCc1ccccc1
- Molecular formula (if other than submission substance):C7H8O
- Molecular weight (if other than submission substance):108.1392 g/mol
- Substance type:Organic
- Physical state:colorless liquid
Specific details on test material used for the study:
Name: Benzyl alcohol
InChI: 1S/C7H8O/c8-6-7-4-2-1-3-5-7/h1-5,8H,6H2
Smiles: OCc1ccccc1
- Molecular formula (if other than submission substance):C7H8O
- Molecular weight (if other than submission substance):108.1392 g/mol
- Substance type:Organic
- Physical state:colorless liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
not specified
Doses:
1230 mg/kg
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 230 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality was observed
Mortality:
50% mortality was observed at 1230 mg/kg bw.
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
LD50 was considered to be 1230 mg/kg bw, when rat was treated with Benzyl alcohol (100-51-6) via oral route.
Executive summary:

Acute oral toxicity study of Benzyl alcohol (100-51-6) was conducted in rat at the concentration of 1230 mg/kg. 50% mortality was observed at 1230 mg/kg bw. Therefore, LD50 was considered to be 1230 mg/kg bw, when rat was treated with Benzyl alcohol via oral route.