2-methoxybenzyl alcohol

Endpoint summary

Description of key information

Short term toxicity to aquatic invertebrates:

Based on the prediction done using the OECD QSAR toolbox version 3.4 with log kow as the primary descriptor and considering the five closest read across substances, toxicity on Daphnia magna predicted for 2-Methoxybenzyl alcohol (612-16-8). Based on the intoxication of daphnia magna the EC50 value was estimated to be 105.647 mg/l when 2-Methoxybenzyl alcohol exposed to Daphnia magna for 48 hrs. Based on this value it can be concluded that the substance 2-Methoxybenzyl alcohol is considered to not toxic to aquatic environment as per the criteria mentioned in CLP regulation. 

Toxicity to aquatic algae and cyanobacteria:

Based on the prediction done using the OECD QSAR toolbox version 3.4 with log kow as the primary descriptor and considering the five closest read across substances, toxicity on Desmodesmus subspicatus (previous name: Scenedesmus subspicatus) predicted for 2-Methoxybenzyl alcohol (612-16-8). Based on the growth inhibition of green algae the EC50 value was estimated to be 407.57 mg/l when 2-Methoxybenzyl alcohol exposed to Desmodesmus subspicatus for 72 hrs. Based on this value it can be concluded that the substance 2-Methoxybenzyl alcohol is considered to not toxic to aquatic environment as per the criteria mentioned in CLP regulation.  

Additional information

Summarized result of toxicity of 2-Methoxybenzyl alcohol (612-16-8) on the growth and other activity of aquatic invertebrates, algae and cyanobacteria by considering the data for target as well as RA chemical which was selected on the basis of structure similarity are as follows:

 

Short term toxicity to aquatic invertebrates:

Based on the various experimental data and prediction data for the target chemical study have been reviewed to determine the toxic nature of disodium 2-Methoxybenzyl alcohol (612-16-8) on the growth of invertebrates. The studies are as mentioned below:

In the first predicted study for the target chemical 2-Methoxybenzyl alcohol (612-16-8) from QSAR toolbox 2017, study was carried out. Based on the prediction done using the OECD QSAR toolbox version 3.4 with log kow as the primary descriptor and considering the five closest read across substances, toxicity on Daphnia magna predicted for 2-Methoxybenzyl alcohol (612-16-8). Based on the intoxication of daphnia magna the EC50 value was estimated to be105.647 mg/l when 2-Methoxybenzyl alcohol exposed to Daphnia magna for 48 hrs. Based on this value it can be concluded that the substance 2-Methoxybenzyl alcohol is considered to not toxic to aquatic environment as per the criteria mentioned in CLP regulation. 

 

Similarly in the second weight of evidence study from EPIsuite, 2017. Based on the prediction done by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC 50 value for short term toxicity to aquatic invertebrates was predicted. On the basis of this program, the LC 50 value for short term toxicity to aquatic invertebrates was predicted to be 341.205 mg/l for 2-Methoxybenzyl alcohol in 48 hrs. Based on this value it can be concluded that the substance 2-Methoxybenzyl alcohol is considered to be not toxic to aquatic environment and cannot be classified as per the criteria mentioned in CLP regulation.

 

In the third experimental weight of evidence study for the RA chemical (98-85-1) ABITEC 2016, Determination of the inhibition of the mobility of daphnids was carried out with the substance 1-phenylethanol according to OECD Guideline 202. The test substance was tested at the limit concentration 100 mg/L. After the exposure of 48hrs to daphnia magna only 4% Daphnia were immobilised at the end of the test. Based on the mortality of daphnia magna due to the exposure of chemical 1-phenylethanol, the inhibitory concentration was 100 mg/l at which only 4% inhibition was observed. Thus median effective concentration (EC50) for the test substance, 1-phenylethanol, in Daphnia magna was determined to be > 100 mg/L for 50% immobilisation effects. This value indicates that the substance is not likely to be hazardous to aquatic invertebrates as per the CLP criteria.

 

Similarly in the fourth weight of evidence study for the read across chemical Benzyl alcohol (100-51-6) from j-check, 2017 Study was conducted to determine the toxic nature of chemical Benzyl alcohol on the growth of aquatic invertebrates (daphnia magna). Test was conducted according to the OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test). Total 48hrs of exposure of chemical was given to the daphnia species. Test was performed in the static system. After the exposure of chemical EC50 was calculated. Based on the immobility of daphnia species, due to the exposure of chemical Benzyl alcohol for 48hrs the EC50 was 230 mg/l. Based on the EC50, it can be concluded that the chemical Benzyl alcohol was consider to be nontoxic and can be consider to be not classified as per the CLP classification criteria.

 

 

Similarly in the fifth weight of evidence study for the read across chemical α-hydroxy-o-tolyl β-D-glucopyranoside (138-52-3) from j-check, 2017 Study was conducted to determine the toxic nature of chemical α-hydroxy-o-tolyl β-D-glucopyranoside on the growth and mobility of aquatic invertebrates. Test was conducted according to the OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test). Total 48hrs of exposure of chemical was given to the daphnia species. Test was performed in the static system. After the exposure of chemical EC50 was calculated. Based on the immobility of test organism, due to the exposure of chemical α-hydroxy-o-tolyl β-D-glucopyranoside for 48hrs the EC50 was > 5000 mg/l. Based on the EC50, it can be concluded that the chemical α-hydroxy-o-tolyl β-D-glucopyranoside was consider to be nontoxic and can be consider to be not classified as per the CLP classification criteria.   

 

Based on the data obtain from various predicted and experimental studies for the toxicity on invertebrates due to the exposure of 2-Methoxybenzyl alcohol (612-16-8) thus it was concluded that the chemical disodium 2-Methoxybenzyl alcohol was consider as nontoxic and can be consider to be not classified as toxic to aquatic invertebrates as per CLP classification criteria. 

 

 

Toxicity to aquatic algae and cyanobacteria:

Based on the various experimental data and prediction data for the target chemical study have been reviewed to determine the toxic nature of 2-Methoxybenzyl alcohol (612-16-8) on the growth of algae. The studies are as mentioned below: 

In the first predicted study for the target chemical 2-Methoxybenzyl alcohol (612-16-8) from QSAR toolbox 2017, study was carried out. Based on the prediction done using the OECD QSAR toolbox version 3.4 with log kow as the primary descriptor and considering the five closest read across substances, toxicity on Desmodesmus subspicatus (previous name: Scenedesmus subspicatus) predicted for 2-Methoxybenzyl alcohol (612-16-8). Based on the growth inhibition of green algae the EC50 value was estimated to be 407.57 mg/l when 2-Methoxybenzyl alcohol exposed to Desmodesmus subspicatus for 72 hrs. Based on this value it can be concluded that the substance 2-Methoxybenzyl alcohol is considered to not toxic to aquatic environment as per the criteria mentioned in CLP regulation.  

 

 

Similarly in the second weight of evidence study from EPIsuite, 2017. Based on the prediction done using the EPI Suite ECOSAR version 1.10, the short term toxicity on green algae was predicted for test substance 2-Methoxybenzyl alcohol (612 -16 -8). On the basis of effects observed in a static freshwater system, the effect concentration EC50 value for the substance is estimated to be 184.182 mg/l for green algae for 72hrs duration. Based on this value, it can be concluded that the test chemical 2-Methoxybenzyl alcohol can be considered as non-toxic to green algae at environmentally relevant concentrations and can be considered not-classified as per the CLP classification criteria.

 

 

In the third experimental weight of evidence study for the RA chemical 1-phenylethanol (98-85-1) ABITEC 2016, Freshwater algal growth inhibition test was carried out on Desmodesmus subspicatus with the substance 1-phenylethanol according to OECD Guideline 201. The test substance was dissolved in DMSO and tested at the concentrations 0 and 100 mg/L. Effects on the growth rate of the organism were studied. Based on the growth inhibition of green algae Desmodesmus subspicatus, due to the 1-phenylethanol, the IC1.5 was 100 mg/l. Thus median effective concentration (EC50) for the test substance, 1-phenylethanol, in Desmodesmus subspicatus was determined to be > 100 mg/L. This value indicates that the substance is not likely to be hazardous to aquatic algae as per the CLP criteria.

 

Similarly in the fourth weight of evidence study for the read across chemical Benzyl alcohol (100-51-6) from j-check 2017, Study was conducted to determine the toxic nature of chemical Benzyl alcohol on the growth of aquatic green algae. Test was performed according to the OECD Guideline 201 (Alga, Growth Inhibition Test). Green algae exposed for 72hrs with the chemical. Test conducted by the static system. After the exposure of chemical, the effect concentration and no observed effect concentration was measured. Based on the growth rate inhibition of green algae the EC50 and NOEC was 770 mg/l and 310 mg/l. Based on the Area under the growth curved (AUG), the EC50 and NOEC was 500 and 310 mg/l by the exposure of chemical Benzyl alcohol for 72hrs. Thus it was concluded that the chemical was nontoxic and can be consider to be not classified as per the CLP classification criteria.

 

Based on the data obtain from various predicted and experimental studies for the toxicity on invertebrates due to the exposure of 2-Methoxybenzyl alcohol (612-16-8) thus it was concluded that the chemical 2-Methoxybenzyl alcohol was consider as nontoxic and can be consider to be not classified as toxic to aquatic invertebrates as per CLP classification criteria. 

 

Based on the data obtain from various sources for evaluating the toxicity of target chemical 2-Methoxybenzyl alcohol (612-16-8), on the invertebrates and algal growth, it can be concluded that the substance for 2-Methoxybenzyl alcohol (612-16-8) is considered to be nontoxic and can be consider to be not classified as toxic to aquatic environment as per CLP classification criteria.