Registration Dossier
Registration Dossier
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EC number: 229-054-5 | CAS number: 6408-31-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from safety assessment report
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Environment and Quality of Life - Reports (Seventh Series)
- Author:
- European Commission (EC) - Scientific Committee on Cosmetology (SCC)
- Year:
- 1 988
- Bibliographic source:
- Environment and Quality of Life - Reports (Seventh Series), European Commission (EC) - Scientific Committee on Cosmetology (SCC),1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- The skin irritation study of chemical Sodium 4-(3-hydroxy-5-methyl-4-phenylazopyrazol-2-yl)benzenesulphonate (CAS No: 6359-82-6) was conducted on rabbits to assess the degree of irritation caused by the chemical.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium 4-(3-hydroxy-5-methyl-4-phenylazopyrazol-2-yl)benzenesulphonate
- EC Number:
- 228-808-0
- EC Name:
- Sodium 4-(3-hydroxy-5-methyl-4-phenylazopyrazol-2-yl)benzenesulphonate
- Cas Number:
- 6359-82-6
- Molecular formula:
- C16H14N4O4S.Na
- IUPAC Name:
- Sodium 4-(3-hydroxy-5-methyl-4-phenylazopyrazol-2-yl)benzene sulphonate
- Test material form:
- solid
- Details on test material:
- -Name: Acid yellow 11
- Molecular formula: C16H13N4NaO4S
-Molecular weight: 380.359 g/mol
-Substance type: organic
- InChI: 1S/C16H14N4O4S.Na/c1-11-15(18-17-12-5-3-2-4-6-12)16(21)20(19-11)13-7-9-14(10-8-13)25(22,23)24;/h2-10,15H,1H3,(H,22,23,24);/q;+1/p-1/b18-17+;
-Smiles: N1(c2ccc(S(=O)(=O)[O-])cc2)C([C@@H](\N=N\c2ccccc2)C(=N1)C)=O.[Na+]
- Substance Type: Organic
- Physical State: Solid
Constituent 1
- Specific details on test material used for the study:
- -Name: Acid yellow 11
- Molecular formula: C16H13N4NaO4S
-Molecular weight: 380.359 g/mol
-Substance type: organic
- InChI: 1S/C16H14N4O4S.Na/c1-11-15(18-17-12-5-3-2-4-6-12)16(21)20(19-11)13-7-9-14(10-8-13)25(22,23)24;/h2-10,15H,1H3,(H,22,23,24);/q;+1/p-1/b18-17+;
-Smiles: N1(c2ccc(S(=O)(=O)[O-])cc2)C([C@@H](\N=N\c2ccccc2)C(=N1)C)=O.[Na+]
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- other: intact and abraded skin
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 100% (100mg)
- Duration of treatment / exposure:
- No data available
- Observation period:
- No data available
- Number of animals:
- No data available
- Details on study design:
- No data available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No skin irritating effects were observed in treated rabbits.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not irritating
- Conclusions:
- The test material Sodium 4-(3-hydroxy-5-methyl-4-phenylazopyrazol-2-yl)benzenesulphonate (CAS No: 6359-82-6) was considered to be not irritating to the skin of rabbits.
- Executive summary:
Skin irritation study of chemicalSodium 4-(3-hydroxy-5-methyl-4-phenylazopyrazol-2-yl)benzenesulphonate(CAS No:6359-82-6) was conducted on intact and abraded skin of rabbits to assess the degree of skin irritation caused by the chemical.
When rabbits were exposed with 100 mg of undilutedSodium 4-(3-hydroxy-5-methyl-4-phenylazopyrazol-2-yl)benzenesulphonate(CAS No:6359-82-6), no skin irritating effects were observed.
Thus the chemicalSodium 4-(3-hydroxy-5-methyl-4-phenylazopyrazol-2-yl)benzenesulphonate(CAS No:6359-82-6) was considered to be not irritating to the rabbits’skin.
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