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EC number: 237-185-4 | CAS number: 13680-35-8
This study was performed to investigate the potential gene mutagenic activity of the test item according to the plate incorporation test of Ames et. al. (1) using the Salmonella typhimurium strains TA 98, TA 100, TA 1535, TA 1537 and TA 1538. The test was performed with and without liver microsomal activation. The test material was tested at the following concentrations: 1.58, 5, 15.8, 50, 158, 500, 1580 and 5000 micrograms per plate. Each concentration, including the controls, was tested in triplicate. No toxic effect of the test material was observed. Up to the highest investigated dose, no relevant increase of the revertant colony numbers was obtained in any Salmonella typhimurium strain when compared with the corresponding controls. The presence of microsomal activation did not influence these findings. In conclusion, it can be stated that during this in vitro Salmonella/mammalian-microsome assay, no gene mutagenic activity could be demonstrated under the experimental conditions reported.
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