Registration Dossier
Registration Dossier
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EC number: 209-294-7 | CAS number: 565-80-0
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 2,4-dimethylpentan-3-one
- EC Number:
- 209-294-7
- EC Name:
- 2,4-dimethylpentan-3-one
- Cas Number:
- 565-80-0
- Molecular formula:
- C7H14O
- IUPAC Name:
- 2,4-dimethylpentan-3-one
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in report): 2,4-Dimethylpentanon-3 / Diisopropyl keton
- Physical state: liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test substance (as cited in report): 2,4-Dimethyl-3-pentone
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD(SD)BR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Weight at study initiation: Males 284 - 297 g, Females 227 - 235 g
- Identification: Alll animals were identified by metal ear tags/cage number.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Dorsal skin (The hair from the dorsal skin of the rats was removed with an electric clipper).
- Type of wrap if used: Occlusive
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 20 mL/kg bw - Doses:
- 20 mL/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs, body weight - Statistics:
- Method of calculation: Weil method
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 20 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: corresponds to 16200 mg/kg bw (based on a relative density of 0.81)
- Mortality:
- No mortality occurred
- Clinical signs:
- other: No clinical signs were note during the 14 day observation period.
- Gross pathology:
- not reported
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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