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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from authoritative database

Data source

Reference
Reference Type:
other: Authoritative database
Title:
HSDB for the CAS: 100-21-0
Author:
U S National Library of Medicine
Year:
2012
Bibliographic source:
Hazardous Substance Databank (HSDB), U S National Library of Medicine, last updated 2012

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To assess the dermal irritation potential of terephthalic acid in humans
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid
Details on test material:
Name of the test chemical:Terephthalic acid
Molecular Formula:C8H6O4
Molecular Weight:166.131 g/mol
SMILES notation: c1(C(O)=O)ccc(C(O)=O)cc1
Substance Type:Organic
Physical State: Solid
Specific details on test material used for the study:
Name of the test chemical:Terephthalic acid
Molecular Formula:C8H6O4
Molecular Weight:166.131 g/mol
SMILES notation: c1(C(O)=O)ccc(C(O)=O)cc1
Substance Type:Organic
Physical State: Solid

Test animals

Species:
other: humans
Strain:
not specified
Details on test animals and environmental conditions:
no data available

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
other: oily paste
Controls:
not specified
Amount / concentration applied:
10 ml application of an oily paste containing 80% terephthalic acid
Duration of treatment / exposure:
no data available
Observation period:
no data available
Number of animals:
no data available
Details on study design:
TEST SITE
- Area of exposure: equal sites on the hand

Results and discussion

In vitro

Other effects / acceptance of results:
no data available

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: no data available
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No irritation observed

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
Terephthalic acid when applied as an oily paste was not irritating to human skin.
Executive summary:

The dermal irritation potential of terephthalic acid was assessed in humans.

10 ml oily paste containing 80% terephthalic acid was applied to the equal sites on the hands of human volunteers (number not specified).The volunteers were observed for signs of irritation (duration not specified).

Terephthalic acid when applied as an oily paste was not irritating to human skin.